INT186136

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.06
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD2) plasma membrane (CD2)
Anatomy Link Frequency
hinge 2
T cell 2
CD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 81 99.52 Very High Very High Very High
Arthritis 118 98.88 Very High Very High Very High
methotrexate 4 89.60 High High
rheumatoid arthritis 61 82.88 Quite High
psoriasis 39 80.88 Quite High
backache 1 67.84 Quite High
cytokine 33 17.80 Low Low
abatacept 2 14.88 Low Low
Adalimumab 6 12.04 Low Low
Infliximab 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 39 99.70 Very High Very High Very High
INFLAMMATION 77 99.52 Very High Very High Very High
Seronegative Spondarthritis 92 98.88 Very High Very High Very High
Skin Diseases 3 94.92 High High
Arthritis 30 89.08 High High
Autoimmune Disease 20 84.36 Quite High
Rheumatoid Arthritis 61 82.88 Quite High
Psoriasis 49 80.88 Quite High
Adhesions 7 70.28 Quite High
Low Back Pain 1 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.
Negative_regulation (blockade) of CD2 Binding (interaction) of in T cell associated with inflammation, disease and arthritis
1) Confidence 0.29 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.23 Pain Relevance 0.44
Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).
Negative_regulation (blocked) of CD2 Binding (Interaction) of in hinge
2) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.84 Pain Relevance 0.24

General Comments

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