INT186136

Context Info Confidence 0.29 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.06 Pain Relevance 0.68

extracellular region (CD2) plasma membrane (CD2)

Anatomy Link Frequency hinge 2 T cell 2 CD2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 81 99.52 Arthritis 118 98.88 methotrexate 4 89.60 rheumatoid arthritis 61 82.88 psoriasis 39 80.88 backache 1 67.84 cytokine 33 17.80 abatacept 2 14.88 Adalimumab 6 12.04 Infliximab 18 5.00

Disease Link Frequency Relevance Heat Disease 39 99.70 INFLAMMATION 77 99.52 Seronegative Spondarthritis 92 98.88 Skin Diseases 3 94.92 Arthritis 30 89.08 Autoimmune Disease 20 84.36 Rheumatoid Arthritis 61 82.88 Psoriasis 49 80.88 Adhesions 7 70.28 Low Back Pain 1 67.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study supports the notion that T cell activation plays an important role in chronic inflammatory diseases and effective blockade of the LFA-3/CD2 interaction may be useful for treating PsA.

Negative_regulation (blockade) of CD2 Binding (interaction) of in T cell associated with inflammation, disease and arthritis

1) Confidence 0.29 Published 2005 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1208938 Disease Relevance 1.23 Pain Relevance 0.44

Interaction of CD2 with its ligand, CD58 has been blocked by application of a soluble fully human recombinant fusion protein comprising the first extracellular domain of CD58 and the hinge, CH2 and CH3 sequences of human IgG1 (LFA-3-IgG1; alefacept).

Negative_regulation (blocked) of CD2 Binding (Interaction) of in hinge

2) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.84 Pain Relevance 0.24

General Comments

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