INT186147

Context Info Confidence 0.45 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.95 Pain Relevance 0.04

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1) cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)

Camk4 (Mus musculus) Creb1 (Mus musculus)

Pain Link Frequency Relevance Heat Eae 4 75.44 analgesia 15 32.16 antidepressant 2 23.76 tail-flick 4 5.00 amygdala 2 5.00 Neuropeptide 2 5.00 Analgesic 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 58 100.00 Targeted Disruption 3 94.28 Disease 1 76.64 Schizophrenia 1 75.28 Cancer 1 72.80 Stress 34 56.88 Post-traumatic Stress Disorder 3 5.00 Nociception 3 5.00 Aggression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These studies further suggest that CaMKIV may play an important role in anxiety-like behavior through its regulation of CREB since CREB mutant mice displayed alterations in emotional behavior [5,7,25].

CaMKIV Spec (like) Regulation (role) of Regulation (regulation) of CREB associated with anxiety disorder

1) Confidence 0.45 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.95 Pain Relevance 0.04

General Comments

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