INT186148

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)
Camk4 (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 15 84.08 Quite High
antidepressant 2 72.80 Quite High
Hippocampus 3 52.32 Quite High
amygdala 3 51.28 Quite High
Anterior cingulate cortex 1 50.48 Quite High
Somatosensory cortex 1 48.32 Quite Low
Neuropeptide 2 30.64 Quite Low
Eae 19 5.00 Very Low Very Low Very Low
tail-flick 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 34 85.80 High High
Sprains And Strains 7 82.72 Quite High
Anxiety Disorder 120 80.24 Quite High
Manic Depressive Disorder 1 68.20 Quite High
Schizophrenia 4 67.36 Quite High
Targeted Disruption 77 58.80 Quite High
Aggression 2 34.64 Quite Low
Shock 5 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 4 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKIV may also play a role in CREB phosphorylation by modulating other kinase pathways.
CaMKIV Positive_regulation (role) of Phosphorylation (phosphorylation) of CREB
1) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.71 Pain Relevance 0.32
CaMKIV phosphorylates CREB and the phosphorylation is terminated by calcineurin, possibly through direct CREB dephosphorylation or through activation of the downstream protein phosphatase 1 [19].
CaMKIV Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of CREB
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.40 Pain Relevance 0.08

General Comments

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