INT186151

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)
Camk4 (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 94 79.44 Quite High
Eae 20 75.44 Quite High
analgesia 15 32.16 Quite Low
antidepressant 2 23.76 Low Low
amygdala 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
tail-flick 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 126 100.00 Very High Very High Very High
Targeted Disruption 17 94.28 High High
Disease 1 76.64 Quite High
Schizophrenia 1 75.28 Quite High
Cancer 1 72.80 Quite High
Stress 36 56.88 Quite High
Post-traumatic Stress Disorder 23 53.12 Quite High
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies further suggest that CaMKIV may play an important role in anxiety-like behavior through its regulation of CREB since CREB mutant mice displayed alterations in emotional behavior [5,7,25].
CaMKIV Regulation (regulation) of CREB associated with anxiety disorder
1) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.95 Pain Relevance 0.04
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) controls activity-dependent gene transcription by regulating the activity of the cyclic AMP response element binding protein (CREB).
CaMKIV Regulation (regulating) of CREB
2) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2219998 Disease Relevance 0.05 Pain Relevance 0.11
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) controls activity-dependent gene transcription by regulating the activity of the cyclic AMP response element binding protein (CREB).
CaMKIV Regulation (regulating) of cyclic AMP response element binding protein
3) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2219998 Disease Relevance 0.05 Pain Relevance 0.11

General Comments

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