INT186152

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Context Info
Confidence 0.27
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1)
cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)
Camk4 (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatosensory cortex 1 98.12 Very High Very High Very High
Anterior cingulate cortex 1 97.24 Very High Very High Very High
amygdala 5 96.16 Very High Very High Very High
Hippocampus 4 95.76 Very High Very High Very High
antidepressant 4 92.36 High High
Neuropeptide 4 24.08 Low Low
analgesia 30 5.00 Very Low Very Low Very Low
Eae 23 5.00 Very Low Very Low Very Low
tail-flick 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 68 97.12 Very High Very High Very High
Anxiety Disorder 178 96.68 Very High Very High Very High
Sprains And Strains 7 53.16 Quite High
Targeted Disruption 80 50.00 Quite Low
Manic Depressive Disorder 1 38.64 Quite Low
Schizophrenia 5 37.80 Quite Low
Post-traumatic Stress Disorder 7 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Shock 5 5.00 Very Low Very Low Very Low
Aggression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcium-calmodulin-dependent protein kinase IV (CaMKIV) plays a role in the activity-dependent phosphorylation of cyclic AMP-responsive element binding protein (CREB) and CRE modulator (CREM), which regulate the expression of genes involved in neuroplasticity [1], learning and memory [2-4], emotional behavior [5-7] and molecular changes induced by antidepressants [8].
CaMKIV Regulation (plays) of Phosphorylation (phosphorylation) of cyclic AMP-responsive element binding protein associated with antidepressant
1) Confidence 0.27 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.19 Pain Relevance 0.05
Calcium-calmodulin-dependent protein kinase IV (CaMKIV) plays a role in the activity-dependent phosphorylation of cyclic AMP-responsive element binding protein (CREB) and CRE modulator (CREM), which regulate the expression of genes involved in neuroplasticity [1], learning and memory [2-4], emotional behavior [5-7] and molecular changes induced by antidepressants [8].
kinase IV Regulation (plays) of Phosphorylation (phosphorylation) of cyclic AMP-responsive element binding protein associated with antidepressant
2) Confidence 0.23 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.19 Pain Relevance 0.05
CaMKIV plays a role in the activity-dependent phosphorylation of CREB, which regulates the expression of genes involved in neuroplasticity [24], learning and memory [25], [26], and emotional behaviors [27], [28].
CaMKIV Regulation (plays) of Phosphorylation (phosphorylation) of CREB
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.05 Pain Relevance 0.19

General Comments

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