INT18616

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Context Info
Confidence 0.33
First Reported 1986
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 2.04
Pain Relevance 13.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
neuronal 2
joint 2
spinal 2
tail 2
neurons 2
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 41 100.00 Very High Very High Very High
Dopamine 13 100.00 Very High Very High Very High
Glutamate receptor 10 100.00 Very High Very High Very High
adenocard 10 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
gABA 1 100.00 Very High Very High Very High
Glutamate 12 99.98 Very High Very High Very High
Morphine 32 99.96 Very High Very High Very High
antinociception 18 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 15 99.86 Very High Very High Very High
Nociception 42 99.52 Very High Very High Very High
Anxiety Disorder 1 98.24 Very High Very High Very High
Pressure And Volume Under Development 9 96.10 Very High Very High Very High
Inflammatory Pain 2 96.00 Very High Very High Very High
Pain 20 95.92 Very High Very High Very High
Convulsion 2 95.76 Very High Very High Very High
Syndrome 1 86.64 High High
Hypothermia 1 78.28 Quite High
Hypersensitivity 1 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since activation of either supraspinal or spinal alpha(2) adrenergic receptors can induce antinociception, and since improgan showed affinity for these receptors in vitro, the effects of the alpha(2) antagonist yohimbine on improgan antinociception were presently studied in rats on the hot plate and tail flick tests.
Positive_regulation (induce) of Positive_regulation (activation) of receptors in tail associated with antinociception, antagonist and tail-flick
1) Confidence 0.33 Published 2001 Journal Brain Res. Section Abstract Doc Link 11743967 Disease Relevance 0 Pain Relevance 0.93
Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).
Positive_regulation (induces) of Positive_regulation (stimulation) of receptors associated with antinociception, hyperalgesia, nociceptor and delta opioid receptors
2) Confidence 0.23 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 17113929 Disease Relevance 0.30 Pain Relevance 0.93
Indeed, a significant decrease in the spinal release of CGRPLM release could be evoked by the combined addition of U 50488 H (10 microM) plus DAGO (10 microM) to the perfusing medium, indicating that the simultaneous stimulation of both kappa and mu receptors is required for this negative control to occur.
Positive_regulation (required) of Positive_regulation (stimulation) of receptors in spinal
3) Confidence 0.23 Published 1993 Journal Brain Res. Section Abstract Doc Link 8389648 Disease Relevance 0 Pain Relevance 0.79
Because membrane depolarization through (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors is believed to be necessary for full activation of NMDA receptors, we determined the role of AMPA receptors in morphine-induced c-Fos expression.
Positive_regulation (necessary) of Positive_regulation (activation) of receptors associated with nmda receptor, glutamate receptor and morphine
4) Confidence 0.13 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809699 Disease Relevance 0 Pain Relevance 0.74
The activity was not blocked by bicuculline methiodide or gabazine, but was reversibly abolished by kynurenic acid, indicating that activation of glutamate receptors, but not GABA-A receptors, was required.
Positive_regulation (required) of Positive_regulation (activation) of receptors associated with gaba and glutamate receptor
5) Confidence 0.10 Published 2003 Journal Cereb. Cortex Section Abstract Doc Link 12631570 Disease Relevance 0 Pain Relevance 0.38
Data from both sections and homogenates showed an increase in the capacity of mu binding sites following chronic bremazocine treatment, suggesting that up-regulation of mu receptors had occurred, and that residual ligand from the in vivo treatment had largely been removed.
Positive_regulation (occurred) of Positive_regulation (up-regulation) of receptors
6) Confidence 0.09 Published 1989 Journal Neuroscience Section Abstract Doc Link 2542839 Disease Relevance 0 Pain Relevance 0.56
In the presence of the Na+ channel antagonist, TTX (0.5 microM), glutamate increased [Ca2+]c by activating different glutamate receptors depending on the glutamate concentration used.
Positive_regulation (increased) of Positive_regulation (activating) of receptors associated with tetrodotoxin, glutamate, glutamate receptor and antagonist
7) Confidence 0.04 Published 2003 Journal J. Cell. Sci. Section Abstract Doc Link 12746490 Disease Relevance 0 Pain Relevance 1.19
Thus, the inhibiting effect of bremazocine and probably U-50,488 seems to be derived from stimulation of the kappa receptors which in turn activates a GH release inhibiting mechanism of unknown identify which, however, does not involve release of somatostatin.
Positive_regulation (derived) of Positive_regulation (stimulation) of receptors associated with somatostatin
8) Confidence 0.03 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3001566 Disease Relevance 0 Pain Relevance 1.03
Both the antinociceptive and toxic effects (convulsions and hypertension) were abolished by pretreatment with the brain penetrant neuronal nAChR antagonist mecamylamine (1 mg/kg s.c.; i.v. for cardiovascular studies), demonstrating that these actions of ABT-594 were mediated via activation of neuronal nicotinic receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of receptors in neuronal associated with pressure and volume under development, convulsion, antagonist and antinociceptive
9) Confidence 0.03 Published 2000 Journal Pain Section Abstract Doc Link 10781917 Disease Relevance 0.52 Pain Relevance 0.73
Stimulation of D1 dopamine receptors results in increased expression of mRNA encoding dynorphin as well as expression of immediate-early genes such as c-fos in these neurons.
Positive_regulation (results) of Positive_regulation (Stimulation) of receptors in neurons associated with dynorphin and dopamine receptor
10) Confidence 0.03 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7745131 Disease Relevance 0 Pain Relevance 0.72
The ability of DPCPX to block the effect of UP 202-56, in contrast to the lack of effect of DMPX, increased evidence for a predominant role of adenosine A1 receptors activation in the mechanism of action of UP 202-56.
Positive_regulation (increased) of Positive_regulation (activation) of receptors associated with adenocard
11) Confidence 0.02 Published 1998 Journal Pain Section Abstract Doc Link 9583764 Disease Relevance 0.48 Pain Relevance 0.54
Because activation of NMDA receptors mediates morphine-induced c-Fos expression, we tested the hypothesis that activation of nNOS is involved in this cascade.
Positive_regulation (mediates) of Positive_regulation (activation) of receptors associated with nmda receptor and morphine
12) Confidence 0.02 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.82
Activation of DA receptors by 7 daily injections of APO (5 mg/kg, Bid, s.c.), however, caused a large increase (3- to 4-fold of saline control) in striatal levels of DN-LI and prodynorphin mRNA on the 6-OHDA lesioned side, which is far greater than the increase on the contralateral side (2-fold of saline control).
Positive_regulation (caused) of Positive_regulation (Activation) of receptors associated with dopamine
13) Confidence 0.02 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1977070 Disease Relevance 0.08 Pain Relevance 0.52
The antinociception induced by beta-endorphin administered intrathecally is mediated by the activation of mu- and kappa-opioid receptors in the rat.
Positive_regulation (mediated) of Positive_regulation (activation) of receptors associated with antinociception, nociceptor and kappa opioid receptor
14) Confidence 0.02 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 7643909 Disease Relevance 0 Pain Relevance 1.10
Phosphorylation of serine 897 on NR1 results in the accumulation of NMDA receptors in synapses [12].
Positive_regulation (results) of Positive_regulation (accumulation) of receptors in synapses associated with nmda receptor
15) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.06 Pain Relevance 0.81
Our data suggest that i.t. galanin-produced antinociception is mediated by activation of GalR1 receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of receptors associated with antinociception
16) Confidence 0.01 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610237 Disease Relevance 0 Pain Relevance 1.05
Furthermore, LPS-induced nociception in the primed joint is mediated to a large extent via endothelin release and activation of ET(B) receptors within the joint itself.
Positive_regulation (mediated) of Positive_regulation (activation) of receptors in joint associated with nociception
17) Confidence 0.00 Published 1998 Journal Pain Section Abstract Doc Link 9808351 Disease Relevance 0.42 Pain Relevance 0.22
The changes--neophobia in the open field, an increased and more persistent emotional response to a stressful stimulus, and increased EEG arousal response to an external pain signalling stimulus--suggest an increased reactivity of the system or systems responsible for the induction of fear; c) direct intrahypothalamic injections of CVP, unlike those of oxotremorine, a direct stimulant of cholinergic muscarinic receptors, did not induce overt changes in the animal (rabbit) behaviour and EEG.
Neg (not) Positive_regulation (induce) of Positive_regulation (stimulant) of receptors in external associated with pain and anxiety disorder
18) Confidence 0.00 Published 1997 Journal Int J Occup Med Environ Health Section Abstract Doc Link 9575664 Disease Relevance 0.19 Pain Relevance 0.13

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