INT186163

Context Info Confidence 0.34 First Reported 2004 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 12 Total Number 13 Disease Relevance 4.23 Pain Relevance 1.45

RNA binding (NOVA2) nucleus (NOVA2)

Anatomy Link Frequency lateral 2 neurite 2 interneurons 2 NOVA2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 53 96.20 cytokine 21 95.28 Spinal cord 72 87.92 fluoxetine 18 85.52 Bile 1 81.76 Dopamine 50 78.56 Hippocampus 14 73.16 Hyperalgesia 5 70.72 allodynia 14 69.36 amygdala 44 67.00

Disease Link Frequency Relevance Heat Necrosis 112 100.00 Stress 82 99.12 Injury 147 97.72 Toxicity 53 97.30 Hepatotoxicity 17 96.92 INFLAMMATION 69 96.20 Anxiety Disorder 28 94.24 Aging 23 93.88 Cancer 19 80.32 Apoptosis 30 79.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Post hoc tests are routinely applied in such situations, whether the overall ANOVA was significant or not.

Spec (whether) Positive_regulation (overall) of Spec (whether) Gene_expression (overall) of ANOVA

1) Confidence 0.34 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2496911 Disease Relevance 0 Pain Relevance 0.31

Significant increases in both participant cortisol-levels (repeated-measures ANOVA, pre?

Positive_regulation (increases) of Gene_expression (measures) of ANOVA

2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713432 Disease Relevance 0.47 Pain Relevance 0.06

The interactions between age classes and testing events were not significant (Two-way RM-ANOVA LIO: F8, 636?

Positive_regulation (-) of Gene_expression (way) of ANOVA

3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779852 Disease Relevance 0 Pain Relevance 0

17.31, p<0.001; Fig. 2a and 2b) and the age classes (Two-way RM-ANOVA: LIO: F2, 159?

Positive_regulation (-) of Gene_expression (17.31) of ANOVA

4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779852 Disease Relevance 0 Pain Relevance 0

g/ml produced a modest neurite toxicity, this was not robustly observed when subsequent experiments were performed (the effect was not significant when all data was analysed using ANOVA with a Bonferroni post-hoc test, although a direct comparison of control versus Cisplatin 1 ?

Positive_regulation (versus) of Gene_expression (using) of ANOVA in neurite associated with toxicity

5) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950519 Disease Relevance 0.74 Pain Relevance 0

RIA assays (Figure 1D) demonstrated large increases in pYE27 (mixed design ANOVA, Treatment × Side interaction: F3,15?

Positive_regulation (increases) of Gene_expression (mixed) of ANOVA

6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.05 Pain Relevance 0.10

When the ANOVA produced significant results, we then performed the post hoc Fisher’s protected least-significant difference test for comparisons between groups.

Positive_regulation (When) of Gene_expression (produced) of ANOVA

7) Confidence 0.04 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.34 Pain Relevance 0.03

IL-6 deficiency attenuated the age-related loss of PV-interneurons (Fig. 4c); two-way ANOVA analysis of the genotype×age interaction showed a statistically significant effect for area CA3 (F(1,23)?

Positive_regulation (way) of Gene_expression (analysis) of ANOVA in interneurons

8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.21 Pain Relevance 0.15

Estimated fiber length was not significantly different (One-way ANOVA: F?

Neg (not) Positive_regulation (different) of Neg (not) Gene_expression (different) of One-way ANOVA

9) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.40 Pain Relevance 0.03

8) had a significant increase in percentage of REM sleep (two-way ANOVA, for treatment×day/night, F2, 42?

Positive_regulation (way) of Gene_expression (sleep) of ANOVA

10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0

The western blots for NR2A indicated no significant change in the expression of protein (ANOVA on raw data, p > 0.05) (Figure 7).

Neg (no) Positive_regulation (change) of Gene_expression (expression) of ANOVA

11) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.39 Pain Relevance 0.50

To identify the genes that are significantly differentially expressed among the different levels of necrosis, an unbalanced one-way ANOVA was fitted for each gene,

Positive_regulation (fitted) of Gene_expression (expressed) of ANOVA associated with necrosis

12) Confidence 0.03 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 1.25 Pain Relevance 0.09

ANOVA: analysis of variance; BSA: bovine serum albumin; IVN: inferior vestibular nucleus; LVN: lateral vestibular nucleus; MVN: medial vestibular nucleus; NF?

Positive_regulation (variance) of Gene_expression (analysis) of ANOVA in lateral

13) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.38 Pain Relevance 0.18

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