INT186197

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.93
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SCARB2) enzyme binding (SCARB2)
Anatomy Link Frequency
plaques 1
SCARB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 18 94.04 High High
Angina 24 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 150 99.20 Very High Very High Very High
Gauchers Disease 86 97.66 Very High Very High Very High
Atherosclerosis 234 95.96 Very High Very High Very High
Disorder Of Lipid Metabolism 108 95.56 Very High Very High Very High
Disease 25 64.60 Quite High
Hypoxia 84 35.92 Quite Low
Cv General 3 Under Development 24 5.00 Very Low Very Low Very Low
Infection 14 5.00 Very Low Very Low Very Low
Targeted Disruption 13 5.00 Very Low Very Low Very Low
Myocardial Infarction 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human SR-BII isoform was also detected in macrophages and atherosclerotic plaques.
Gene_expression (detected) of SR-BII isoform in plaques associated with atherosclerotic plaque
1) Confidence 0.40 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.53 Pain Relevance 0.05
A peroxisomal targeting sequence (PTS1) is present in the C-terminal domain of SR-BI, which is not present in the SR-BII and SR-BIII isoforms [8,24].
Neg (not) Gene_expression (present) of SR-BII
2) Confidence 0.35 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.15 Pain Relevance 0
SR-BI (476 bp) and SR-BII (347 bp) transcripts were detected in all the samples examined (Figure 3B).
Gene_expression (detected) of SR-BII
3) Confidence 0.35 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.49 Pain Relevance 0
We have previously identified a PTS1 motif in the C-terminus of SR-BI [8,24], which is not present in SR-BII and SR-BIII.
Neg (not) Gene_expression (present) of SR-BII
4) Confidence 0.35 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.66 Pain Relevance 0.04
As an isoform of SR-BI, SR-BII, is expressed in mouse tissue and human cell lines, primers able to detect both isoforms were used (Figure 3A).
Gene_expression (expressed) of SR-BII
5) Confidence 0.31 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.09 Pain Relevance 0
Lower surface expression or reduced stability of SR-BII compared to SR-BI may contribute to the differences between the two molecules [24].
Gene_expression (expression) of SR-BII
6) Confidence 0.31 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.51 Pain Relevance 0.04
Rare variant forms of Gaucher disease result from deficiency of the sphingolipid activator protein, saposin C.3 Latterly, inherited defects in a recently discovered molecule, LIMP-2, have been associated with an usual phenotype with ?
Gene_expression (discovered) of LIMP-2 associated with gauchers disease
7) Confidence 0.14 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.51 Pain Relevance 0

General Comments

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