INT186199

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.25
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SCARB1) small molecule metabolic process (SCARB1) cell adhesion (SCARB1)
plasma membrane (SCARB1) lipid metabolic process (SCARB1) cytoplasm (SCARB1)
Anatomy Link Frequency
blood 2
SCARB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 8 99.92 Very High Very High Very High
fibrosis 14 91.68 High High
Inflammatory response 2 64.24 Quite High
Inflammation 30 50.00 Quite Low
cytokine 40 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 40 99.96 Very High Very High Very High
Hepatitis C Virus Infection 144 98.46 Very High Very High Very High
Hepatocellular Cancer 152 93.44 High High
Cirrhosis 56 91.68 High High
Atherosclerotic Plaque 50 90.64 High High
Atherosclerosis 78 90.40 High High
Hepatitis B Virus Infection 20 88.68 High High
Liver Cancer 22 82.68 Quite High
Infection 42 79.00 Quite High
Hypoxia 28 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SR-BI mainly binds phospholipid-rich HDL particles, whereas ABCA1 preferably uses lipid-poor HDL particles as cholesterol acceptors [31].
SR-BI Binding (binds) of associated with disorder of lipid metabolism
1) Confidence 0.37 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.72 Pain Relevance 0
Scavenger receptor class B type I (SR-BI) binds HDL and mediates selective uptake of cholesterol ester and cellular efflux of cholesterol to HDL.
Scavenger receptor class B type I Binding (binds) of associated with disorder of lipid metabolism
2) Confidence 0.35 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1215476 Disease Relevance 0.68 Pain Relevance 0.05
In the blood of infected patients, HCV is associated with blood lipoprotein VLDL, LDL, and HDL; although the virus binds to different molecules it requires tetraspanin CD81, the scavenger receptor class B type I (SR-BI), the tight junction proteins claudin (CLDN1) and occludin [17-20] to entry into hepatocytes.
scavenger receptor class B type I Binding (binds) of in blood associated with hepatitis c virus infection and disorder of lipid metabolism
3) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.92 Pain Relevance 0.08
In the blood of infected patients, HCV is associated with blood lipoprotein VLDL, LDL, and HDL; although the virus binds to different molecules it requires tetraspanin CD81, the scavenger receptor class B type I (SR-BI), the tight junction proteins claudin (CLDN1) and occludin [17-20] to entry into hepatocytes.
SR-BI Binding (binds) of in blood associated with hepatitis c virus infection and disorder of lipid metabolism
4) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.92 Pain Relevance 0.08

General Comments

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