INT18621

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Context Info
Confidence 0.36
First Reported 1984
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 9.88
Pain Relevance 18.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 2
cerebral cortex 1
basal ganglia 1
neural 1
dental pulp 1
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 665 100.00 Very High Very High Very High
Gabapentin 106 100.00 Very High Very High Very High
Dopamine 91 100.00 Very High Very High Very High
agonist 80 100.00 Very High Very High Very High
Serotonin 60 100.00 Very High Very High Very High
Neurotransmitter 45 100.00 Very High Very High Very High
Glutamate 36 100.00 Very High Very High Very High
Opioid 33 100.00 Very High Very High Very High
opiate 16 100.00 Very High Very High Very High
GABA receptor 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 191 100.00 Very High Very High Very High
Disease 22 99.56 Very High Very High Very High
Alcohol Addiction 53 99.54 Very High Very High Very High
Post Operative Pain 8 99.12 Very High Very High Very High
Breast Cancer 3 99.00 Very High Very High Very High
Pain 153 98.80 Very High Very High Very High
Schizophrenia 142 97.48 Very High Very High Very High
Neuropathic Pain 3 94.12 High High
Hyperalgesia 4 93.56 High High
Depression 88 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gabapentin does not bind to GABA(A) or GABA(B) receptors.
GABA Neg (not) Binding (bind) of associated with gaba and gabapentin
1) Confidence 0.36 Published 2003 Journal CNS Drugs Section Abstract Doc Link 14533947 Disease Relevance 0.44 Pain Relevance 1.09
Gabapentin does not bind to GABA(A) or GABA(B) receptors.
GABA Neg (not) Binding (bind) of associated with gaba and gabapentin
2) Confidence 0.36 Published 2003 Journal CNS Drugs Section Abstract Doc Link 14533947 Disease Relevance 0.39 Pain Relevance 1.03
Therefore, an investigation of a direct influence of GABA-A agonist propofol, GABA-A and PBR-agonist etomidate, and the local anesthetic drug lidocaine, which can also bind to the GABA-A receptor and PBR, on migration of breast carcinoma cells was performed.
GABA Binding (bind) of associated with gaba, breast cancer, agonist, lidocaine and local anesthetic
3) Confidence 0.33 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.35 Pain Relevance 0.49
For example, laboratory evidence has generally supported the ability of GABA to reduce dopaminergic activity, and has suggested that GABA may be effective in combating hypofrontality by acting on the mesoprefrontocortical tracts in patients resistant to treatment with antipsychotic drugs.12,13 As a result, it has been claimed by some investigators that it might be possible to decrease negative symptoms and cognitive impairment in people with schizophrenia by treatment with glutamatergic drugs.13
GABA Binding (ability) of associated with cognitive disorder, gaba and schizophrenia
4) Confidence 0.32 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.40 Pain Relevance 0.33
It posits that studying in utero cannabis exposure in association with genetic mutations of neural systems that have strong relationships to endocannabinoid function, such as the dopamine, opioid, glutamate, and GABA, might help to identify individuals at risk.
GABA Spec (might) Binding (association) of in neural associated with endocannabinoid, gaba, glutamate, dopamine, cannabis and opioid
5) Confidence 0.32 Published 2009 Journal Eur Arch Psychiatry Clin Neurosci Section Abstract Doc Link 19568685 Disease Relevance 0.15 Pain Relevance 0.70
Finally, there were three layers which contained peaks in binding for ligands for opioid, GABA and beta adrenoceptors.
GABA Binding (binding) of associated with gaba and opioid
6) Confidence 0.31 Published 1990 Journal Neuroscience Section Abstract Doc Link 1977100 Disease Relevance 0 Pain Relevance 0.66
The binding of ligands for muscarinic acetylcholine, serotonin, opioid, GABA and beta adrenoceptors was evaluated.
GABA Binding (binding) of associated with gaba, opioid and serotonin
7) Confidence 0.31 Published 1990 Journal Neuroscience Section Abstract Doc Link 1977100 Disease Relevance 0 Pain Relevance 0.37
Although numerous other receptors (e.g., GABA, nicotinic acetylcholine, opiate, voltage-operated channels) have been reported to interact with ketamine, their role in inducing dissociative anaesthesia is still under discussion.
GABA Binding (interact) of associated with gaba, ketamine and opiate
8) Confidence 0.31 Published 1997 Journal Anaesthesist Section Abstract Doc Link 9163274 Disease Relevance 0 Pain Relevance 0.72
GABA and its associated benzodiazepine interactions play an important role in basal ganglia function.
GABA Binding (interactions) of in basal ganglia associated with gaba
9) Confidence 0.31 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6089057 Disease Relevance 0.17 Pain Relevance 0.23
Despite being configurationally similar to GABA (known to be an inhibitory transmitter in the brain), gabapentin does not bind to GABA receptors.
GABA Neg (not) Binding (bind) of in brain associated with gaba, gaba receptor and gabapentin
10) Confidence 0.31 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.86 Pain Relevance 0.96
1) Clinical reports of central pain relief after the administration of intrathecal baclofen, a GABA-B agonist.2–6 2) Clinical trials in which tricyclic antidepressant therapy produce analgesia presumably through reversal of GABA inhibition.7 3) Laboratory reports in animals in which application of GABA in the cerebral cortex produced analgesia and intrathecal GABA antagonists produced allodynia and hyperalgesia.8
GABA Binding (inhibition.7) of in cerebral cortex associated with pain, central pain, allodynia, tricyclic antidepressant, analgesia, gaba, hyperalgesia, antagonist, agonist, cerebral cortex and intrathecal
11) Confidence 0.29 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.93 Pain Relevance 1.89
There are many subtypes of GABA receptors, evolving through permutations of the subunits that may explain why GABA deficiency is associated with many disease states.16 Matching a specific GABA receptor subtype agonist to the variable lesions of central pain and introducing a subtype specific GABA agonist into the delicate CNS would be a significant undertaking.
GABA Binding (associated) of associated with pain, central pain, gaba, gaba receptor, agonist, central nervous system and disease
12) Confidence 0.28 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 0.83 Pain Relevance 1.22
The most commonly prescribed GABA agonist, baclofen, binds to the metabotropic heterodimeric GABA-B receptor and is not antagonized by bicuculline, a GABA-A agonist.14 Because oral dosing poorly permeates the blood brain barrier (BBB), intrathecal baclofen therapy is indicated for the treatment of spasticity from pyramidal tract disease or multiple sclerosis and has been reported to relieve central pain.2–5 Intrathecal administration of any medication has many potential problems, including infection, bleeding, catheter migration, obstruction of tubing, replacement of generators, granuloma formation, refilling mishaps and expense.15 This author believes that spinal infusion of a GABAergic medication is not a sustainable long-term therapy for the large number of patients who suffer from central pain.


GABA Binding (binds) of in brain associated with pain, central pain, spasticity, hemorrhage, granuloma, disease, infection, gaba, multiple sclerosis, gabaergic, agonist and intrathecal
13) Confidence 0.28 Published 2010 Journal Perspect Medicin Chem Section Body Doc Link PMC2918363 Disease Relevance 1.19 Pain Relevance 1.55
GABA-mediated presynaptic and postsynaptic inhibition is believed to be related to the direct interaction of propofol with the GABA receptor complex [69].
GABA Binding (interaction) of associated with gaba and gaba receptor
14) Confidence 0.23 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.26 Pain Relevance 0.34
Baclofen, a GABA(B) agonist, evoked GTPgamma35S binding in both human and bovine dental pulp.
GABA Binding (binding) of in dental pulp associated with gaba and agonist
15) Confidence 0.22 Published 2001 Journal J Endod Section Abstract Doc Link 11592491 Disease Relevance 0 Pain Relevance 0.75
Consistent with previous observations, thiocolchicoside also inhibited the binding of GABA to rat cerebral cortical membranes.
GABA Binding (binding) of associated with gaba
16) Confidence 0.17 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17234181 Disease Relevance 0.07 Pain Relevance 0.43
In recent years, many medications have been evaluated for the treatment of alcohol dependence, including those that interact with dopaminergic, serotonergic, opioid or glutamate and/or GABA systems.
GABA Binding (interact) of associated with addiction, gaba, glutamate, opioid and alcohol
17) Confidence 0.12 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2899994 Disease Relevance 0.95 Pain Relevance 0.86
These suggest that in teens and young adults the pool of on-demand GABA can be readily replenished and binds with ?
GABA Binding (binds) of associated with gaba
18) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0 Pain Relevance 0.18
1), with the mature subunit conferring faster receptor decay times and great affinity for GABA compared with the immature subunits.
GABA Binding (affinity) of associated with gaba
19) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.22 Pain Relevance 0.08
1 subunit also has high-affinity for binding GABA and benzodiazepine receptor ligands (Pritchett et al., 1989).
GABA Binding (binding) of associated with gaba
20) Confidence 0.07 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.15 Pain Relevance 0.19

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