INT186266

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.26
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf1) DNA binding (Irf1)
Anatomy Link Frequency
proximal 1
Irf1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 28 98.44 Very High Very High Very High
Inflammation 101 95.52 Very High Very High Very High
ischemia 26 87.36 High High
Central nervous system 7 84.00 Quite High
metalloproteinase 3 83.76 Quite High
cytokine 96 82.48 Quite High
agonist 1 68.52 Quite High
Inflammatory response 13 26.12 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 165 100.00 Very High Very High Very High
Targeted Disruption 14 97.28 Very High Very High Very High
INFLAMMATION 122 95.52 Very High Very High Very High
Infection 197 91.96 High High
Death 12 88.12 High High
Cv Unclassified Under Development 26 87.36 High High
Cold Sores 214 82.68 Quite High
Adhesions 15 82.08 Quite High
Endotoxemia 6 74.80 Quite High
Acute Renal Failure 3 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, luteolin down-regulated complement factor 3, which is regulated by AP1 [68] and blocked expression of Slpi, which is a target of interferon regulatory factor 1 (IRF1) [69].
Gene_expression (expression) of IRF1
1) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.46 Pain Relevance 0.15
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Gene_expression (expression) of Irf1
2) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.24 Pain Relevance 0.11
A recent study has demonstrated that IRF-1 is an early critical proinflammatory signal stimulated by reactive oxygen species during ischemic injury in vitro and in vivo and is produced within S3 proximal tubule cells.
Gene_expression (produced) of IRF-1 in proximal associated with injury
3) Confidence 0.18 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.58 Pain Relevance 0.31
This results in reduced expression of the transcription factor IRF-1, which is crucial for induction of iNOS [440].
Gene_expression (expression) of IRF-1
4) Confidence 0.18 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.98 Pain Relevance 0.07

General Comments

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