INT186269

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.70
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 209 99.92 Very High Very High Very High
cytokine 206 99.62 Very High Very High Very High
antagonist 44 98.60 Very High Very High Very High
cINOD 5 63.44 Quite High
Serotonin 2 60.00 Quite High
dexamethasone 18 59.64 Quite High
chemokine 25 55.68 Quite High
aspirin 16 50.00 Quite Low
Inflammatory response 4 47.52 Quite Low
corticosteroid 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 210 99.92 Very High Very High Very High
Asthma 388 99.76 Very High Very High Very High
Rhinitis 62 99.48 Very High Very High Very High
Hypersensitivity 138 98.84 Very High Very High Very High
Adhesions 11 97.80 Very High Very High Very High
Hyperplasia 19 96.56 Very High Very High Very High
Eosinophilia 33 95.56 Very High Very High Very High
Lung Injury 1 93.64 High High
Pneumonia 7 93.48 High High
Apoptosis 89 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although IL-13 is associated with asthma and atopy, no studies have evaluated its association with AIA.
IL-13 Binding (associated) of associated with asthma and rhinitis
1) Confidence 0.39 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.33 Pain Relevance 0.10
However IL-13 binds to the IL13Ra1 subunit rather then the IL4Ra subunit (reviewed [13]).
IL-13 Binding (binds) of
2) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.51 Pain Relevance 0.19
Several studies have shown an association between IL-13 and high serum total IgE levels, bronchial hyper-responsiveness, and asthma.10,12 IL-13 polymorphisms have population-specific effects.
IL-13 Binding (association) of associated with asthma
3) Confidence 0.31 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 0.97 Pain Relevance 0.06
The H4R and IL-13 also both appear to mediate allergic airway dysfunction.
IL-13 Binding (The) of associated with hypersensitivity
4) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.02 Pain Relevance 0.32
In addition, it significantly decreased the release of Th2-specific cytokines into the BALF, as exemplified by IL-5 and IL-13 measurements.
IL-13 Binding (exemplified) of associated with cytokine
5) Confidence 0.21 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 1.18 Pain Relevance 0.42
IL-13 is also recognized to regulate eosinophilic inflammation, and mucus secretion [29].
IL-13 Binding (recognized) of associated with rhinitis and inflammation
6) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 1.01 Pain Relevance 0.27
On the other hand, combination of IL-13 and IFN-?
IL-13 Binding (combination) of
7) Confidence 0.11 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.58 Pain Relevance 0.13
IL-13 binds to three complexes: A high-affinity heterodimer of IL-13R?
IL-13 Binding (binds) of
8) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.13 Pain Relevance 0.14
and IL-1 interact synergistically with IL-4 and IL-13 to augment VCAM-1 expression as well as intercellular adhesion molecule-1 (ICAM-1, CD54) expression.94 Recent data suggest that TNF-?
IL-13 Binding (interact) of associated with adhesions
9) Confidence 0.04 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.96 Pain Relevance 0

General Comments

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