INT186270

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 11.58
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lung 3
alternatively activated macrophages 1
T cells 1
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 275 100.00 Very High Very High Very High
antagonist 82 100.00 Very High Very High Very High
tolerance 29 99.24 Very High Very High Very High
fibrosis 279 98.94 Very High Very High Very High
Inflammation 607 98.52 Very High Very High Very High
chemokine 38 90.64 High High
Inflammatory response 45 87.28 High High
metalloproteinase 2 53.72 Quite High
dexamethasone 18 50.32 Quite High
corticosteroid 4 49.12 Quite Low
Disease Link Frequency Relevance Heat
Asthma 204 99.60 Very High Very High Very High
Toxoplasmosis 9 99.36 Very High Very High Very High
Fibrosis 207 99.16 Very High Very High Very High
Pulmonary Fibrosis 216 98.94 Very High Very High Very High
INFLAMMATION 605 98.52 Very High Very High Very High
Yersinia Infection 1 96.76 Very High Very High Very High
Targeted Disruption 26 96.44 Very High Very High Very High
Infection 337 95.56 Very High Very High Very High
Rheumatoid Arthritis 13 94.24 High High
Toxicity 9 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes promoting immune responses were down-regulated, including genes for the proinflammatory/Th2 cytokines IL-1b, IL-4, IL-6, IL-10, IL-13, and TNF-?.
Regulation (regulated) of IL-13 associated with cytokine
1) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.04 Pain Relevance 0.52
Down-regulation of Th2 cytokine genes (Il4, Il10, Il13), as described in our data, has been reported in alloreactive T cells in which tolerance has been induced and immune rejection suppressed (Taylor et al. 2002).
Regulation (regulation) of Il13 in T cells associated with tolerance and cytokine
2) Confidence 0.43 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.03 Pain Relevance 0.54
For example, pulmonary fibroblasts from IPF patients have spontaneously elevated levels of IL-13 and IL-4 receptor subunits, and it has been suggested that the abnormal proliferative properties of lung fibroblasts from certain lung fibrosis patient groups can be modulated in a manner that is dependent on the IL-4 and IL-13 receptor expression [10].
Regulation (dependent) of IL-13 in lung associated with fibrosis and pulmonary fibrosis
3) Confidence 0.22 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.88 Pain Relevance 0.44
We therefore sought to examine whether the previously reported modulation of IL-13, and other Th2 cytokines, by H4R antagonists could have a meaningful therapeutic effect on inflammation, remodeling and airway dysfunction in a sub-chronic model of allergic lung inflammation in the mouse

Methods

Regulation (modulation) of IL-13 in lung associated with inflammation, antagonist, hypersensitivity, pneumonia and cytokine
4) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.96 Pain Relevance 0.30
Consequently, we utilized another well-described model to initiate airway hyperreactivity and to examine the effect of H4R antagonists and anti-IL-13 on this parameter.
Spec (examine) Regulation (effect) of anti-IL-13 associated with asthma and antagonist
5) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.81 Pain Relevance 0.12
Because IL-4, IL-6, IL-13 and NRAMP are very important in immunity to toxoplasmosis and could play a pathogenic role in the inflammatory process we observed, mice without IL-4, IL-6, IL-13, or Nramp, infected for shorter times, were also studied to determine whether these cytokines or immune processes were necessary and sufficient for the perivascular cuffing and meningeal and parenchymal abnormalities we had observed.
Regulation (important) of IL-13 associated with inflammation, congenital anomalies, toxoplasmosis and cytokine
6) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.22 Pain Relevance 0.23
The concentrations of IL-4, IL-5, IL-10, and IL-13 (R & D system, Minneapolis, MN, USA) in the BALF were measured using enzyme-linked immunosorbent assay (ELISA) kits, according to the manufacturer's instructions.


Regulation (concentrations) of IL-13
7) Confidence 0.12 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0 Pain Relevance 0
Thirdly, TLR2 mediated the HSP60-stimulated the expression of Stat3-controled suppressive factors, such as IL-10, IL-13, TGF-?
Regulation (controled) of IL-13
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.69 Pain Relevance 0.03
[249-251].The Th2 cytokines of the other side of the adaptive response, IL-4 and IL-13, inhibit IL-12 induction in the early phases of stimulation, but later they can be potent inducers of IL-12 production, although they still inhibit many of the IFN-?
Regulation (response) of IL-13 associated with cytokine
9) Confidence 0.10 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.29 Pain Relevance 0.23
Nano particles with antigen increased protein levels of interleukin (IL)-5, IL-6, and IL-13, eotaxin, macrophage chemoattractant protein (MCP)-1, and regulated on activation and normal T cells expressed and secreted (RANTES) in the lung as compared with antigen alone.
Regulation (regulated) of IL-13 in lung
10) Confidence 0.08 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1242256 Disease Relevance 0.57 Pain Relevance 0.20
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of IL-13
11) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.57 Pain Relevance 0.34
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of IL-13
12) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.35 Pain Relevance 0.29
No similar effect on the levels of IL-4, IL-13 or IFN-?
Neg (No) Regulation (effect) of IL-13
13) Confidence 0.06 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 0.97 Pain Relevance 0.41
Production of type II cytokines such as IL-4, IL-10 and IL-13 which can modulate the macrophages to become more anti-inflammatory type alternatively activated macrophages (aaM?)
Regulation (modulate) of IL-13 in alternatively activated macrophages associated with inflammation and cytokine
14) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 1.21 Pain Relevance 0.54

General Comments

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