INT186272

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.45
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
macrophages 3
lung 2
dendritic cells 1
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 158 93.36 High High
headache 7 83.84 Quite High
psoriasis 55 63.92 Quite High
Arthritis 13 62.00 Quite High
Inflammation 64 61.04 Quite High
Central nervous system 17 5.00 Very Low Very Low Very Low
Etanercept 17 5.00 Very Low Very Low Very Low
Multiple sclerosis 11 5.00 Very Low Very Low Very Low
Potency 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 9 99.84 Very High Very High Very High
Hyperplasia 3 97.72 Very High Very High Very High
Sprains And Strains 48 97.68 Very High Very High Very High
Cancer 209 97.16 Very High Very High Very High
Death 14 96.76 Very High Very High Very High
Pneumonia 40 96.44 Very High Very High Very High
Common Cold 4 88.00 High High
Nasopharyngitis 3 85.20 High High
Headache 7 83.84 Quite High
Infection 424 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A collaborative action of dendritic cells and macrophages could be important, as indicated for IL-12 induction by influenza virus and other inducers [241].
Positive_regulation (indicated) of Positive_regulation (induction) of IL-12 in macrophages associated with influenza virus infection
1) Confidence 0.26 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.27 Pain Relevance 0
This kind of analysis is considered a conservative method, so the outstanding long-term efficacy rates yielded by those studies could possibly be underestimation of the real potential of this IL-12 and IL-23 inhibitor.42
Positive_regulation (underestimation) of Positive_regulation (potential) of IL-12
2) Confidence 0.22 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.54 Pain Relevance 0.15
showed significantly increased IL-12 and NO induction compared with untreated groups.
Positive_regulation (increased) of Neg (NO) Positive_regulation (induction) of IL-12
3) Confidence 0.18 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2892347 Disease Relevance 0.38 Pain Relevance 0
An effective intranasal conjugate pneumococcal vaccine using interleukin-12 (IL-12) as a mucosal adjuvant induced protection and increased expression of lung and splenic IFN-?
Positive_regulation (using) of Positive_regulation (induced) of IL-12 in lung
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.87 Pain Relevance 0.21
TAMs with the M1 phenotype are characterized by a high capacity to present antigen, high IL-12 and IL-23 production, and high production of toxic intermediates, such as nitric oxide and reactive oxygen intermediates.
Positive_regulation (present) of Positive_regulation (high) of IL-12
5) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 1.05 Pain Relevance 0
TAMs with the M1 phenotype are characterized by a high capacity to present antigen, high IL-12 and IL-23 production, and high production of toxic intermediates, such as nitric oxide and reactive oxygen intermediates.
Positive_regulation (capacity) of Positive_regulation (present) of IL-12
6) Confidence 0.15 Published 2010 Journal J Transl Med Section Body Doc Link PMC2841127 Disease Relevance 1.06 Pain Relevance 0
A collaborative action of dendritic cells and macrophages could be important, as indicated for IL-12 induction by influenza virus and other inducers [241].
Positive_regulation (indicated) of in dendritic cells Positive_regulation (induction) of IL-12 in macrophages associated with influenza virus infection
7) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.27 Pain Relevance 0

General Comments

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