INT186273

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 22.88
Pain Relevance 8.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13) extracellular region (Il13) cytoplasm (Il13)
Anatomy Link Frequency
lung 3
eosinophils 2
lymph node 1
macrophages 1
goblet cell 1
Il13 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1061 100.00 Very High Very High Very High
cytokine 769 100.00 Very High Very High Very High
dexamethasone 90 99.98 Very High Very High Very High
antagonist 292 99.68 Very High Very High Very High
agonist 29 99.60 Very High Very High Very High
lidocaine 102 99.42 Very High Very High Very High
isoflurane 40 95.60 Very High Very High Very High
metalloproteinase 7 89.12 High High
chemokine 98 87.68 High High
tolerance 25 69.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1109 100.00 Very High Very High Very High
Asthma 791 100.00 Very High Very High Very High
Hyperplasia 129 99.66 Very High Very High Very High
Hypersensitivity 505 99.36 Very High Very High Very High
Adhesions 57 98.92 Very High Very High Very High
Nicotine Addiction 47 98.48 Very High Very High Very High
Cold Sores 214 98.24 Very High Very High Very High
Pneumonia 49 98.20 Very High Very High Very High
Infection 502 98.08 Very High Very High Very High
Sprains And Strains 115 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-5 and IL-13 levels in the tissue may also be reduced by a direct effect on Th2 cell cytokine elaboration.
Negative_regulation (reduced) of IL-13 in Th2 cell associated with cytokine
1) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.35 Pain Relevance 0.39
In addition, levels of IL-5 and IL-13 in OVA-stimulated culture supernatants were significantly decreased by H4R antagonist and anti-IL-13 treatment.
Negative_regulation (decreased) of IL-13 associated with antagonist
2) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.18 Pain Relevance 0.32
These effects were recapitulated by H4R antagonist treatment and in support of a direct relationship of these remodeling parameters to IL-13 levels, the extent of their amelioration by JNJ 7777120 was proportional to its reduction of IL-13 levels in the tissue.
Negative_regulation (reduction) of IL-13 associated with antagonist
3) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.00 Pain Relevance 0.35
Consistent down-regulation of critical inflammatory genes in ETS- and doubly OVA-exposed mice was confirmed through qRT-PCR, revealing down-regulation of 17 asthma-related and/or inflammatory genes (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Slc7a2, Il4, Il6, Il10, Il13, Il1b, Tnfa).
Negative_regulation (regulation) of Il13 associated with asthma, nicotine addiction and inflammation
4) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.16 Pain Relevance 0.52
Deficiency in IL4, IL13 and NRAMP are not sufficient to abrogate this inflammatory process.
Negative_regulation (Deficiency) of IL13 associated with inflammation
5) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 1.19 Pain Relevance 0.31
Whilst these effects on goblet cell hyperplasia, collagen deposition and airway hyperreactivity supported the premise that H4R may modulate chronic remodeling through modulation of IL-13 production, other anti-inflammatory effects of H4R antagonism appear to be independent of the reduction in IL-13, since they were not recapitulated by anti-IL-13 treatment.
Negative_regulation (reduction) of IL-13 in goblet cell associated with asthma, inflammation and hyperplasia
6) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.76 Pain Relevance 0.28
After therapeutic treatment with the H4R antagonist, significantly reduced levels of IL-13 were detected compared to vehicle treatment in the BALF (vehicle, 22.3 ± 2.2 pg/ml versus 5 mg/kg H4R, 12.3 ± 2.1 pg/ml P < 0.01) (Fig 1B), and in the tissue (vehicle, 0.24 ± 0.03 pg/ml versus 5 mg/kg H4R, 0.12 ± 0.01 pg/?
Negative_regulation (reduced) of IL-13 associated with antagonist
7) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.51 Pain Relevance 0.35
In this previous study decreases in IL-4, IL-5 and IL-13 were also demonstrated in ovalbumin stimulated lymph node cultures from H4R antagonist treated or H4R deficient mice, despite any effect on proliferation.
Negative_regulation (decreases) of IL-13 in lymph node associated with antagonist
8) Confidence 0.34 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.29 Pain Relevance 0.44
Similarly, the IL-13 concentration was reduced to 35.8 ± 4.4 pg/ml by beta-escin treatment, which represented an inhibitory effect of 43.8% compared to the positive control group (63.7 ± 9.5 pg/ml).
Negative_regulation (reduced) of IL-13
9) Confidence 0.33 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.29 Pain Relevance 0.31
In agreement with its central role in goblet cell differentiation treatment with anti-IL-13 almost completely abolished antigen induced GCH (vehicle, 3.9 ± 0.35 versus anti-IL-13, 0.36 ± 0.09 pix/perimeter airway, P < 0.01 )

Total lung collagen

Negative_regulation (0.35) of anti-IL-13 in lung associated with hyperplasia
10) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.71 Pain Relevance 0.18
We considered that this action may be due to inhibiting IL-13,
Negative_regulation (inhibiting) of IL-13
11) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 1.07 Pain Relevance 0.15
of asthma through suppression of IL-13, IL-5, IgE, eosinophils CCR3 expression, and CD11b
Negative_regulation (suppression) of IL-13 in eosinophils associated with asthma
12) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.78 Pain Relevance 0.07
The reduction in BAL IL-13 levels would
Negative_regulation (reduction) of IL-13
13) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.09
Allergic airway inflammation was suppressed, which was exemplified by the reduction of leucocytes, eosinophils, IL-5 and IL-13 in the bronchoalveolar lavage fluid.
Negative_regulation (reduction) of IL-13 in eosinophils associated with inflammation and hypersensitivity
14) Confidence 0.24 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC2898835 Disease Relevance 1.42 Pain Relevance 0.14
Again this effect was comparable to the reference compound, because dexamethasone reduced the IL-13 concentration to 28.2 ± 7.0 pg/ml (inhibition of 55.7%).
Negative_regulation (reduced) of IL-13 associated with dexamethasone
15) Confidence 0.24 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.19 Pain Relevance 0.27
Based on this study we decided to perform the collection of BALF for the evaluation of IL-5 and IL-13 cytokines at 15 h after the last challenge.
Negative_regulation (evaluation) of IL-13 associated with cytokine
16) Confidence 0.24 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.38 Pain Relevance 0.31
Anti-inflammatory effect of sTNFR was accompanied with reduction of T helper 2 cytokine levels including interleukin (IL)-4, IL-5 and IL-13 in BALF and vascular cell adhesion molecule 1 expression in lung tissue.


Negative_regulation (reduction) of IL-13 in lung associated with inflammation, adhesions and cytokine
17) Confidence 0.19 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2730622 Disease Relevance 0.95 Pain Relevance 0.24
To date, no studies have been able to demonstrate in vivo the effect of a cell-specific inhibition of the IL-13/IL-4R?
Negative_regulation (inhibition) of IL-13
18) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.88 Pain Relevance 0.12
By day 10 PI, intestinal IL-13 levels were reduced in IL-4R??
Negative_regulation (reduced) of IL-13
19) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.19 Pain Relevance 0.20
There was also a clear trend towards reduction of secreted IL-13 in Cerk-/- animals (- 45%; p = 0.10 vs WT), which was observed neither with Sphk1-/- nor with Sphk2-/- animals.
Negative_regulation (reduction) of IL-13
20) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.39 Pain Relevance 0.26

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