INT186277

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.15
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
NK cell 1
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 48 99.76 Very High Very High Very High
cytokine 144 96.84 Very High Very High Very High
cINOD 1 93.84 High High
addiction 2 77.36 Quite High
Inflammation 51 75.16 Quite High
Spinal cord 5 74.96 Quite High
chemokine 14 68.64 Quite High
Central nervous system 43 68.24 Quite High
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 70 99.76 Very High Very High Very High
Inflammatory Bowel Disease 54 99.36 Very High Very High Very High
Cold Sores 428 99.20 Very High Very High Very High
Infection 394 95.72 Very High Very High Very High
INFLAMMATION 54 93.60 High High
Ileal Diseases 5 89.60 High High
Multiple Sclerosis 46 83.60 Quite High
Central Nervous System Disease 25 68.24 Quite High
Viral Infection 30 64.88 Quite High
Spinal Cord Diseases 1 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that SNPs within CCR6, STAT3, JAK2, IL23R, IL12B, the IL22/IL26 and the IL2/IL21 gene cluster have been found to be associated with CD and or UC, we should take in mind the influence of these SNPs on Th17 cytokine profiles.
IL12B Binding (associated) of associated with inflammatory bowel disease, crohn's disease and cytokine
1) Confidence 0.20 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.51 Pain Relevance 0.29
IL-12 was first described as an NK cell stimulatory factor (NKSF) and identified as a heterodimeric molecule composed of a p40 and a p35 subunit, which are covalently linked [233].
p40 Binding (linked) of in NK cell
2) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.11 Pain Relevance 0.08
B-sequence of the IL-12p40 promoter binds NF-?
IL-12p40 Binding (binds) of
3) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.06 Pain Relevance 0.07
Cells cultured with IL-12p70 up-regulated the Th1-associated transcription factor, T-bet, and secreted IFN-?
IL-12p70 Binding (cultured) of
4) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.47 Pain Relevance 0.11

General Comments

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