INT186278

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.99
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf1) DNA binding (Irf1)
Irf1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 4 98.32 Very High Very High Very High
Paracetamol 122 81.60 Quite High
cytokine 319 50.00 Quite Low
Central nervous system 43 49.56 Quite Low
Inflammation 67 15.96 Low Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
headache 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1183 99.46 Very High Very High Very High
Adhesions 6 99.32 Very High Very High Very High
Cold Sores 1284 99.26 Very High Very High Very High
Depression 4 98.32 Very High Very High Very High
Repression 6 94.00 High High
Toxicity 19 67.32 Quite High
Viral Infection 91 63.76 Quite High
Encephalitis 6 55.36 Quite High
Targeted Disruption 18 36.72 Quite Low
Coronavirus Infection 6 26.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identified family members have antiviral effects in certain cell lines and can be induced by both IRF-1 and STAT1 [48].
IRF-1 Binding (induced) of
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.10 Pain Relevance 0.19
and vascular cell adhesion molecule 1 also involve physical interaction of IRF-1 and NF-?
IRF-1 Binding (interaction) of associated with adhesions
2) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.77 Pain Relevance 0
Further analysis of the signalling mechanism has revealed that the synergism upon HSV infection is influenced by physical interaction of IRF-1 and the NF-?
IRF-1 Binding (interaction) of associated with cold sores and infection
3) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.00 Pain Relevance 0
Furthermore, another mechanism could evolve from the observation that IL-4 signalling can result in disruption of the complex formation of ICSBP and IRF-1 and thereby inhibit iNOS induction [416].
IRF-1 Binding (formation) of
4) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0
Another potential mechanism in the synergistic induction of iNOS could involve complex formation of IFN consensus sequence-binding protein (ICSBP or IRF-8) and IRF-1, which is also important for high-output NO production but has still not been studied in HSV infections [416].
IRF-1 Binding (formation) of associated with cold sores and infection
5) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.82 Pain Relevance 0
This is in agreement with the fact that IRF-2 is known to compete with the binding of IRF-1 to ISRE sites and to antagonize the trans-activating activity of IRF-1 in the regulation of other IFN-induced genes [443-445].
IRF-1 Binding (binding) of
6) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.17 Pain Relevance 0
B [413], and both IRF-1 and IRF-2 have in other cells types been shown to form complexes with NF-?
IRF-1 Binding (complexes) of
7) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.72 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox