INT186283

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 7.92
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 16
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 350 96.68 Very High Very High Very High
addiction 1 74.92 Quite High
Inflammation 11 63.40 Quite High
fibrosis 11 5.00 Very Low Very Low Very Low
peptic ulcer disease 11 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 155 100.00 Very High Very High Very High
Mycobacterial Infection 1243 99.98 Very High Very High Very High
Cold Sores 214 99.50 Very High Very High Very High
Infection 648 96.00 Very High Very High Very High
Sprains And Strains 278 91.20 High High
INFLAMMATION 13 63.40 Quite High
Viral Infection 15 62.44 Quite High
Disease 33 5.00 Very Low Very Low Very Low
Ulcers 22 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B in HSV-infected cells, and the production of IL-12p40 was found to be repressed by an inhibitor of NF-?
Negative_regulation (repressed) of Gene_expression (production) of IL-12p40 associated with cold sores
1) Confidence 0.13 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.94 Pain Relevance 0.07
Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Mycobacterium tuberculosis has evolved many strategies to evade elimination by the host immune system, including the selective repression of macrophage IL-12p40 production.

Negative_regulation (repression) of Gene_expression (production) of IL-12p40 in macrophage associated with mycobacterial infection and repression
2) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Title Doc Link PMC2390761 Disease Relevance 0.75 Pain Relevance 0
To further assess this apparent repression of IL-12p40 production by wild type but not by ?
Negative_regulation (repression) of Gene_expression (production) of IL-12p40 associated with repression
3) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.29 Pain Relevance 0.18
Isolation of M. tuberculosis mutants defective in repression of IL-12p40 production
Negative_regulation (repression) of Gene_expression (production) of IL-12p40 associated with mycobacterial infection and repression
4) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 1.00 Pain Relevance 0
Studies of the mechanisms of immune evasion by M. tuberculosis have revealed that one of the strategies used by the tubercle bacillus to resist eradication is to actively repress macrophage production of IL-12p40 while stimulating secretion of IL-10, an inhibitor of IL-12 mediated-immunity [19],[20].
Negative_regulation (repress) of Gene_expression (production) of IL-12p40 in macrophage associated with mycobacterial infection
5) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.53 Pain Relevance 0.11
Given previous findings on the ability of IL-12 to enhance protective immunity and extend survival in mice and humans infected with M. tuberculosis [12],[23],[24], and the discovery that M. tuberculosis represses IL-12p40 production, we hypothesized that M. tuberculosis actively dampens the production of IL-12p40 cytokine in infected macrophages.
Negative_regulation (represses) of Gene_expression (production) of IL-12p40 in macrophages associated with mycobacterial infection and cytokine
6) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.70 Pain Relevance 0.11
-dimycolate (TDM) was identified as an effector molecule for the repression of IL-12p40 production by M. tuberculosis.
Negative_regulation (repression) of Gene_expression (production) of IL-12p40 associated with mycobacterial infection and repression
7) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.83 Pain Relevance 0.03
In addition, it was apparent from these results that wild type TDMs possessed both weak stimulatory and strong inhibitory activity for macrophage production of IL-12p40, whereas the ?
Negative_regulation (possessed) of Gene_expression (production) of IL-12p40 in macrophage
8) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.32 Pain Relevance 0.06
Consistent with this view, we also showed that TDM from wild type M. tuberculosis repressed macrophage IL-12p40 production.
Negative_regulation (repressed) of Gene_expression (production) of IL-12p40 in macrophage associated with mycobacterial infection
9) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.83 Pain Relevance 0
Analysis of transposon mutants and identification of mmaA4 as a locus involved in repression of IL-12p40 responses in macrophages
Negative_regulation (repression) of Gene_expression (responses) of IL-12p40 in macrophages associated with repression
10) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.36 Pain Relevance 0
Inhibition of IL-12p40 production in macrophages by TDM of wild type M. tuberculosis
Negative_regulation (Inhibition) of Gene_expression (production) of IL-12p40 in macrophages associated with mycobacterial infection
11) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.34 Pain Relevance 0.17
In contrast, purified TDM isolated from wild-type M. tuberculosis inhibited production of IL-12p40 by macrophages.
Negative_regulation (inhibited) of Gene_expression (production) of IL-12p40 in macrophages associated with mycobacterial infection
12) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 1.03 Pain Relevance 0

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