INT186290

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.82
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Pvrl1) plasma membrane (Pvrl1)
Anatomy Link Frequency
intestine 1
neutrophil 1
Pvrl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 18 98.04 Very High Very High Very High
cytokine 189 96.24 Very High Very High Very High
chemokine 11 95.68 Very High Very High Very High
tolerance 31 85.60 High High
corticosteroid 17 84.36 Quite High
Inflammation 116 68.60 Quite High
imagery 29 50.00 Quite Low
alcohol 1 36.40 Quite Low
halothane 2 28.48 Quite Low
Bile 13 15.04 Low Low
Disease Link Frequency Relevance Heat
Infection 390 99.20 Very High Very High Very High
Cold Sores 286 98.34 Very High Very High Very High
INFLAMMATION 124 97.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 95.76 Very High Very High Very High
Herpes Simplex Virus Infection 7 93.80 High High
Shock 11 91.20 High High
Herpes Simplex Virus 14 88.16 High High
Injury 43 87.08 High High
Aspergillus Infection 41 87.08 High High
Autoimmune Disease 54 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pattern recognition receptors (PRR) on AM recognize specific fungal cell wall motifs displayed during the conidial and hyphal stages and produce cytokines and chemokines that stimulate neutrophil recruitment and subsequent antigen-specific immunity.
PRR Binding (recognize) of in neutrophil associated with chemokine and cytokine
1) Confidence 0.11 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2859869 Disease Relevance 1.31 Pain Relevance 0.23
HSV-2 is a human pathogen that readily infects many other species, including mice, by binding to highly conserved entry receptors, especially nectin-1, on epithelial target cell surfaces.
nectin-1 Binding (binding) of associated with cold sores
2) Confidence 0.10 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 1.40 Pain Relevance 0.06
The initial infection is most often asymptomatic, but can be symptomatic depending on the herpesvirus in question and the age and immune status of the host.
herpesvirus Binding (symptomatic) of associated with infection
3) Confidence 0.10 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.78 Pain Relevance 0
PAMP/DAMP in turn are recognized by pattern recognition receptors (PRR), which may be membrane bound or cytoplasmatic.
PRR Binding (bound) of
4) Confidence 0.08 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.17 Pain Relevance 0.06
The binding of a PAMP to a PRR leads to activation of different transcription factors through complex signalling pathways, producing substances increasing the defence against the threatening factor.
PRR Binding (binding) of
5) Confidence 0.08 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.11 Pain Relevance 0
PAMP/DAMP in turn are recognized by pattern recognition receptors (PRR), which may be membrane bound or cytoplasmatic.
PRR Binding (recognized) of
6) Confidence 0.08 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.18 Pain Relevance 0.06
The innate immune response mechanism is either initiated or activated by structures referred to as pathogen-associated molecular patterns (PAMP), which are recognized by corresponding pattern recognition receptors (PRR).
PRR Binding (recognized) of
7) Confidence 0.06 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.39 Pain Relevance 0
On the other hand, L. monocytogenes DNA in the host cell cytoplasm is known to act as a ligand for a hitherto unknown PRR that mediates induction of IFN-?
PRR Binding (ligand) of
8) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.35 Pain Relevance 0
This indicates that PRR mediated recognition of ligands produced by commensal bacteria is involved in positive and negative regulation of both, innate and adaptive immunity in the intestine [7].

7.

PRR Binding (recognition) of in intestine
9) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.12 Pain Relevance 0.04

General Comments

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