INT186292

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
macrophages 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 87 97.72 Very High Very High Very High
Inflammation 77 95.08 Very High Very High Very High
tolerance 1 61.88 Quite High
Pain 18 59.92 Quite High
Multiple sclerosis 2 43.76 Quite Low
Hyperalgesia 3 27.52 Quite Low
withdrawal 1 23.60 Low Low
Central nervous system 7 21.12 Low Low
rheumatoid arthritis 36 5.00 Very Low Very Low Very Low
Osteoarthritis 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 214 98.24 Very High Very High Very High
Infection 198 98.08 Very High Very High Very High
INFLAMMATION 94 95.08 Very High Very High Very High
Repression 2 94.32 High High
Apoptosis 13 89.68 High High
Encephalitis 1 78.32 Quite High
Disease 28 61.52 Quite High
Pain 17 59.92 Quite High
Arthritis 30 50.00 Quite Low
Necrosis 9 48.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ATP stimulation increased expression levels of IL-4, IL-6, IL-13 and TNF-?
Positive_regulation (increased) of Negative_regulation (levels) of IL-4
1) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.79 Pain Relevance 0.34
activated macrophages the IL-4- and IL-13-induced inhibition of iNOS induction can thus be overruled by HSV infection, leading to a sustained NO production (fig. 4) [439,447].
Positive_regulation (activated) of Negative_regulation (inhibition) of IL-4 in macrophages associated with cold sores and infection
2) Confidence 0.12 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.55 Pain Relevance 0.03
, is decreased whereas that of the more suppressive IL-4 and IL-10 is stimulated [45].
Positive_regulation (stimulated) of Negative_regulation (suppressive) of IL-4
3) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.23 Pain Relevance 0.21

General Comments

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