INT186299

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.61
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
smooth muscle cells 1
lung 1
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 61 98.68 Very High Very High Very High
fibrosis 101 96.04 Very High Very High Very High
cytokine 125 89.52 High High
Central nervous system 8 79.88 Quite High
chemokine 10 73.92 Quite High
ischemia 13 61.92 Quite High
Inflammatory response 11 60.16 Quite High
palliative 3 50.00 Quite Low
alcohol 4 37.32 Quite Low
agonist 6 20.56 Low Low
Disease Link Frequency Relevance Heat
Reperfusion Injury 32 99.80 Very High Very High Very High
INFLAMMATION 75 98.68 Very High Very High Very High
Pulmonary Fibrosis 68 96.24 Very High Very High Very High
Infection 237 94.36 High High
Apoptosis 56 91.96 High High
Helminth Infection 25 89.76 High High
Injury 21 88.88 High High
Death 16 83.84 Quite High
Mucositis 74 83.60 Quite High
Fibrosis 58 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, phosphorylated STAT-6 persisted much longer with a more prolonged exposure to IL-4 [24].
Negative_regulation (persisted) of STAT-6
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.17 Pain Relevance 0.04
STAT6 signaling pathway, for instance, is constitutively activated in immature dendritic populations and declines as these cells mature.
Negative_regulation (declines) of STAT6
2) Confidence 0.32 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.19 Pain Relevance 0.09
This contractile ability of intestinal segments and/or smooth muscle cells is abrogated in STAT-6?
Negative_regulation (abrogated) of STAT-6 in smooth muscle cells
3) Confidence 0.31 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.72 Pain Relevance 0.07
Generally, STAT6 was shown to be a key factor in IL-4- and IL-13-induced inhibition of iNOS gene transcription induced by IFN-?
Negative_regulation (shown) of STAT6
4) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.78 Pain Relevance 0.04
In renal IRI, animals lacking the transcriptional factor of the Th2 profile (STAT-6) develop more severe renal damage, while deletion of the Th1 transcriptional factor STAT-4 results in mild protection.
Negative_regulation (lacking) of STAT-6 associated with reperfusion injury
5) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.22 Pain Relevance 0.16
In contrast to deletion of STAT-1 or STAT-6, STAT-3 deletion in mice is lethal and therefore little is known about the role of STAT-3 in lung fibrosis.
Negative_regulation (deletion) of STAT-6 in lung associated with fibrosis and pulmonary fibrosis
6) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940818 Disease Relevance 0.52 Pain Relevance 0.21

General Comments

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