INT18630

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Context Info
Confidence 0.71
First Reported 1990
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.00
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
SK-N-MC 4
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 45 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
noradrenaline 9 98.36 Very High Very High Very High
Enkephalin 18 97.80 Very High Very High Very High
agonist 3 90.04 High High
withdrawal 1 82.92 Quite High
analgesia 1 71.76 Quite High
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 12 99.82 Very High Very High Very High
Lung Cancer 6 99.60 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 7 99.56 Very High Very High Very High
Alcohol Addiction 3 98.54 Very High Very High Very High
Neuroblastoma 3 97.92 Very High Very High Very High
Panic Disorder 3 84.32 Quite High
Substance Withdrawal Syndrome 1 83.28 Quite High
Schizophrenia 1 75.36 Quite High
Mental Disorders 1 73.84 Quite High
Anxiety Disorder 1 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significance of these findings is still unclear and other studies have failed to demonstrate linkage between the polymorphism and alcoholism.8 In this study we examined the function of the C-36 to T transition in transcription of the human CCK gene.
Transcription (transcription) of CCK associated with alcohol addiction and cholecystokinin
1) Confidence 0.71 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.79 Pain Relevance 0.41
The human small-cell lung carcinoma line (SCLC) U-1690 expressed moderate levels of CCK mRNA as compared to the human neuroepithelioma cell line SK-N-MC.
Transcription (expressed) of CCK in SK-N-MC associated with peripheral primitive neuroectodermal tumors, lung cancer, small cell lung cancer and cholecystokinin
2) Confidence 0.71 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.54 Pain Relevance 0.51
The cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropeptides cholecystokinin (CCK), neuropeptide Y, gastrin-releasing peptide (GRP) and enkephalin.
Transcription (expressed) of CCK associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
3) Confidence 0.53 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2384178 Disease Relevance 0.17 Pain Relevance 0.64
The radioimmunoassays showed that the CCK mRNA transcript in the SCLC line U-1690 also is translated, and that preproCCK is processed into bioactive, carboxyamidated CCK peptides.
Transcription (transcript) of CCK associated with small cell lung cancer and cholecystokinin
4) Confidence 0.53 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.54 Pain Relevance 0.53
The human small-cell lung carcinoma line (SCLC) U-1690 expressed moderate levels of CCK mRNA as compared to the human neuroepithelioma cell line SK-N-MC.
Transcription (levels) of CCK in SK-N-MC associated with peripheral primitive neuroectodermal tumors, lung cancer, small cell lung cancer and cholecystokinin
5) Confidence 0.53 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.54 Pain Relevance 0.51
These results suggest that expression of proCCK and proenkephalin A mRNA may be regulated by a similar cAMP-dependent mechanism in the SK-N-MC cell line.
Transcription (expression) of proCCK in SK-N-MC
6) Confidence 0.52 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.07 Pain Relevance 0.16
Regulation of the expression of procholecystokinin (proCCK) and proenkephalin A mRNA was studied in the human neuroblastoma cell line SK-N-MC.
Transcription (expression) of proCCK in SK-N-MC associated with neuroblastoma
7) Confidence 0.52 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.10 Pain Relevance 0.15
ProCCK mRNA levels were increased 1.5-2.5 times by dbcAMP, noradrenaline and isoproterenol when compared with controls.
Transcription (levels) of ProCCK associated with noradrenaline
8) Confidence 0.52 Published 1990 Journal J. Mol. Endocrinol. Section Abstract Doc Link 2157452 Disease Relevance 0.08 Pain Relevance 0.18
The cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropeptides cholecystokinin (CCK), neuropeptide Y, gastrin-releasing peptide (GRP) and enkephalin.
Transcription (expressed) of neuropeptides cholecystokinin associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
9) Confidence 0.46 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 2384178 Disease Relevance 0.17 Pain Relevance 0.64

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