INT186305

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.24
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf1) DNA binding (Irf1)
Irf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 7 84.76 Quite High
metalloproteinase 3 84.16 Quite High
cytokine 59 82.48 Quite High
Inflammation 20 59.84 Quite High
imagery 12 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 197 92.72 High High
Cold Sores 214 83.44 Quite High
Adhesions 3 72.32 Quite High
Coronavirus Infection 1 61.88 Quite High
Severe Acute Respiratory Syndrome 1 61.40 Quite High
INFLAMMATION 23 59.84 Quite High
Influenza Virus Infection 4 59.64 Quite High
Apoptosis 12 57.76 Quite High
Metastasis 61 43.72 Quite Low
Death 8 36.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most conspicuous is activation of the Jak/Stat pathway as indicated by elevated expression of Jak2 and Stat1, decreased expression of Socs1 and increased expression of several Stat target genes (Myc, Irf1, Igsf3g and Usp20) (Fig. 11A).
Positive_regulation (increased) of Gene_expression (expression) of Irf1
1) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.24 Pain Relevance 0.11
This results in reduced expression of the transcription factor IRF-1, which is crucial for induction of iNOS [440].
Positive_regulation (results) of Gene_expression (expression) of IRF-1
2) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.99 Pain Relevance 0.07

General Comments

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