INT186309

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 5.31
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
nucleus 1
lung 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 237 100.00 Very High Very High Very High
depression 4 99.12 Very High Very High Very High
Multiple sclerosis 49 96.16 Very High Very High Very High
Central nervous system 79 95.44 Very High Very High Very High
cytokine 194 93.28 High High
Cannabinoid 33 86.28 High High
agonist 127 84.96 Quite High
Paracetamol 122 82.40 Quite High
addiction 12 61.56 Quite High
ketamine 5 58.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 529 100.00 Very High Very High Very High
INFLAMMATION 276 100.00 Very High Very High Very High
Targeted Disruption 25 99.96 Very High Very High Very High
Dna Damage 51 99.20 Very High Very High Very High
Depression 4 99.12 Very High Very High Very High
Apoptosis 140 98.80 Very High Very High Very High
Stroke 20 97.20 Very High Very High Very High
Demyelinating Disease 34 96.16 Very High Very High Very High
Aging 65 96.12 Very High Very High Very High
Multiple Sclerosis 66 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with our current results these data suggest that STAT1 is tightly associated with resistance to genotoxic stress and provides a promising target for radio-and chemo-sensitization of primary tumors and perhaps distant metastasis.
STAT1 Binding (associated) of associated with dna damage, cancer and metastasis
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.68 Pain Relevance 0.03
For STAT1 phosphorylation, membranes were probed with a phospho-Ser727 STAT1 antibody or a phospho-Tyr701 STAT1 antibody (Cell Signaling Technology, Danvers, MA) and stripped with stripping solution and then re-probed with antibody that recognize total STAT1 (Cell Signaling Technology).


STAT1 Binding (recognize) of
2) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0 Pain Relevance 0
For STAT1 phosphorylation, membranes were probed with a phospho-Ser727 STAT1 antibody (Cell Signaling Technology) and stripped with stripping solution and then re-probed with an antibody that recognizes total STAT1 (Cell Signaling Technology).
STAT1 Binding (recognizes) of
3) Confidence 0.38 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.03
in STAT1H tumor clones is also associated with resistance to ionizing radiation
STAT1H Binding (associated) of associated with cancer
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.56 Pain Relevance 0
To represent progeny of P1 STAT1H and P1 STAT1L cell lines the P2 cell lines were designated as P2H and P2L, respectively.
STAT1H Binding (progeny) of
5) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.25 Pain Relevance 0.03
To represent progeny of P1 STAT1H and P1 STAT1L cell lines the P2 cell lines were designated as P2H and P2L, respectively.
STAT1L Binding (progeny) of
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.25 Pain Relevance 0.03
These results indicate that B16F1 lung colony forming efficiency is significantly associated with expression levels of the IFN/STAT1 pathway.


STAT1 Binding (associated) of in lung
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.18 Pain Relevance 0
Since within seconds after phosphorylation STAT1 translocates into the nucleus for binding to the DNA of its target genes [31], we determined the levels of pSTAT1 in the nuclear fractions of the PEO treated cells.
STAT1 Binding (binding) of in nucleus
8) Confidence 0.31 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
B pathway, such as STAT1 and TLR1; cell proliferation/apoptosis, such as IER3; EHF; LRPAP1 and inflammation such as CCL7; CXCL16; B2M; IL7R and LGALS3 were among the genes whose transcripts were increased in the context of both in vivo aging and in vitro senescence.
STAT1 Binding (as) of associated with aging, inflammation and apoptosis
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.68 Pain Relevance 0.05
The SOCS proteins act as negative regulators of the JAK/STAT1 pathway either by binding and inhibiting JAK tyrosine kinases or by inhibiting binding of STAT1 factors to the cytoplasmic domains of the receptors [56].
STAT1 Binding (binding) of
10) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.28 Pain Relevance 0.26
Alternatively, membranes with identical samples were probed either with phospho-JAK or STAT1, or with an antibody that recognizes total JAK or STAT1.
STAT1 Binding (recognizes) of
11) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.03
Identified family members have antiviral effects in certain cell lines and can be induced by both IRF-1 and STAT1 [48].
STAT1 Binding (induced) of
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.10 Pain Relevance 0.19
In contrast, no interaction was seen between STAT1 and the CK2 polypeptides (Fig. 3A).
STAT1 Neg (no) Binding (interaction) of
13) Confidence 0.26 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
of Stat1 and Stat3 promotes postischemic inflammation, and Stat-1 knockout mice
Stat-1 Binding (inflammation) of associated with targeted disruption and inflammation
14) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.90 Pain Relevance 0.40
R1, which allows binding of the STAT1 homodimer to the receptor and subsequent phosphorylation of STAT1 [204].
STAT1 Binding (binding) of
15) Confidence 0.17 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.18 Pain Relevance 0.13
associates with the protein inhibitor of activated STAT1 (PIAS1), which is a small ubiquitin-like modifier (SUMO)-E3 ligase, in a ligand-dependent manner.
STAT1 Binding (associates) of
16) Confidence 0.11 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.49 Pain Relevance 0.22
In the unphosphorylated state, STAT1 is not recognized by importin-?
STAT1 Binding (recognized) of
17) Confidence 0.07 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0.25 Pain Relevance 0
interacts with the protein inhibitor of the activated transcription factor, STAT-1 (PIAS1).
STAT-1 Binding (interacts) of
18) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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