INT18631

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Context Info
Confidence 0.29
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.24
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 3
blood 1
macrophages 1
DCs 1
nucleus 1
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 28 96.92 Very High Very High Very High
Inflammation 43 80.96 Quite High
cytokine 27 80.16 Quite High
Antihistamine 2 75.00 Quite High
adenocard 4 74.96 Quite High
Inflammatory mediators 2 72.48 Quite High
antagonist 20 71.16 Quite High
Dopamine 24 65.40 Quite High
headache 2 59.84 Quite High
Substantia nigra 34 55.64 Quite High
Disease Link Frequency Relevance Heat
Infection 94 99.56 Very High Very High Very High
Anaphylaxis 5 99.54 Very High Very High Very High
Parkinson's Disease 179 99.16 Very High Very High Very High
Stress 51 96.74 Very High Very High Very High
Increased Venous Pressure Under Development 3 93.44 High High
Respiratory Sounds 1 92.00 High High
Neurocysticercosis 30 90.72 High High
Pox Virus Infection 30 81.24 Quite High
INFLAMMATION 70 80.96 Quite High
Worm Infection 4 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for the concentration of H2, it was reported that H2 dissolved in arterial blood was increased by the inhalation of H2 in proportion to the concentration inhaled, from 0 to 4%, together with O2 and N2O; the amount of H2 dissolved in venous blood was less than that in artery blood, suggesting that H2 had been incorporated into tissues [1].
Positive_regulation (increased) of H2 in blood
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.25 Pain Relevance 0.15
To test whether or not drinking H2/Mg water was effective even after suffering oxidative stress, we compared two different procedures (Figure 3B); one was giving H2/Mg water 7 days prior to the acute MPTP administration (Figure 3B; shown as i) and the other giving H2/Mg water only after MPTP administration (Figure 3B; shown as ii).
Positive_regulation (giving) of H2 associated with parkinson's disease and stress
2) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.81 Pain Relevance 0
-mediated induction of the MHC II gene (H2-Ab1) is impaired in macrophages from aged mice due to the decreased binding of transcription factors to the promoter [64].
Positive_regulation (induction) of MHC II in macrophages
3) Confidence 0.06 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.13 Pain Relevance 0.08
The pathophysiologic effects of histamine in anaphylaxis have been shown to be mediated through H1 and H2 receptors, individually and in combination.
Positive_regulation (mediated) of H2 associated with anaphylaxis
4) Confidence 0.05 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 1977785 Disease Relevance 0.56 Pain Relevance 0.13
The up-regulation of the surface markers, MHC II, CD83 and CD86, was determined after culturing immature DCs in the presence of the DT formulations (Fig. 6).
Positive_regulation (he up-regulat) of MHC II in CD86
5) Confidence 0.04 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003783 Disease Relevance 0.10 Pain Relevance 0
Fig. 6Stimulatory effects of DT formulations on immature DCs as indicated by the up-regulation of the surface markers MHC II, CD83 and CD86.
Positive_regulation (he up-regulat) of MHC II in CD86
6) Confidence 0.04 Published 2010 Journal Pharm Res Section Body Doc Link PMC3003783 Disease Relevance 0 Pain Relevance 0
Studies using whole-cell patch recording demonstrated that histamine excited lateral vestibular nucleus (LVN) neurons by activation of postsynaptic H2 receptors [168].
Positive_regulation (activation) of H2 in nucleus
7) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866460 Disease Relevance 0.06 Pain Relevance 0.10
Likewise, dendritic cells stimulated with helminth components show limited upregulation of CD80, CD86 and MHC-II expression in comparison to the expression induced by bacterial antigens [37].
Positive_regulation (upregulation) of MHC-II in CD86
8) Confidence 0.01 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.67 Pain Relevance 0.08
DCs infected with VV-hTAP1,2 or VV-mTAP1 and incubated with OVA expressed significantly higher numbers of total H-2Kb complexes compared to VV-PJS-5–infected DCs (40% and 30% increase, respectively; p < 0.01) (Figure 5C and 5D).


Positive_regulation (numbers) of H-2Kb
9) Confidence 0.01 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.27 Pain Relevance 0
A subpopulation of splenocytes corresponding to the splenocyte DCs showed a 7.4% increase in total H-2Kb following infection with VV-hTAP1,2 when compared to V-PJS-5 (data not shown).
Positive_regulation (increase) of H-2Kb in DCs associated with infection
10) Confidence 0.00 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.38 Pain Relevance 0

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