INT186346

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf8, Irf1) DNA binding (Irf8, Irf1)
Irf8 (Mus musculus)
Irf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 106 50.00 Quite Low
Central nervous system 14 31.32 Quite Low
Inflammation 22 10.72 Low Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 428 96.40 Very High Very High Very High
Infection 394 96.24 Very High Very High Very High
Repression 2 94.00 High High
Adhesions 2 89.56 High High
Viral Infection 30 63.76 Quite High
Encephalitis 2 55.36 Quite High
Toxicity 6 38.76 Quite Low
INFLAMMATION 26 10.72 Low Low
Coronavirus Infection 2 8.44 Low Low
Targeted Disruption 6 8.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, another mechanism could evolve from the observation that IL-4 signalling can result in disruption of the complex formation of ICSBP and IRF-1 and thereby inhibit iNOS induction [416].
ICSBP Binding (formation) of IRF-1
1) Confidence 0.05 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0
Another potential mechanism in the synergistic induction of iNOS could involve complex formation of IFN consensus sequence-binding protein (ICSBP or IRF-8) and IRF-1, which is also important for high-output NO production but has still not been studied in HSV infections [416].
IRF-8 Binding (formation) of IRF-1 associated with cold sores and infection
2) Confidence 0.05 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.82 Pain Relevance 0

General Comments

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