INT186351

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.77
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) nucleolus (Stat1) nucleus (Stat1)
enzyme binding (Stat1) DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
nucleus 1
Gast (Mus musculus)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 14 87.48 High High
cytokine 110 82.52 Quite High
Inflammation 22 53.88 Quite High
palliative 1 32.56 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 109 98.80 Very High Very High Very High
Infection 394 95.44 Very High Very High Very High
Cold Sores 428 86.16 High High
Coronavirus Infection 2 64.60 Quite High
Severe Acute Respiratory Syndrome 2 64.12 Quite High
Influenza Virus Infection 9 62.36 Quite High
Metastasis 19 56.36 Quite High
INFLAMMATION 26 53.88 Quite High
Lymphatic System Cancer 1 43.28 Quite Low
Disease 2 42.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
STAT1 is phosphorylated by JAK1/2 kinases at the Tyr701 position and then translocates to the nucleus where it binds to GAS (IFN?
GAS Binding (binds) of STAT1 in nucleus
1) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.70 Pain Relevance 0.08
concentrations, IL-4 has been shown to inhibit iNOS induction through STAT6 competition with STAT1 binding to the GAS element of the IRF-1 promoter region.
GAS Binding (binding) of STAT1
2) Confidence 0.03 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.03 Pain Relevance 0.07
concentrations, IL-4 has been shown to inhibit iNOS induction through STAT6 competition with STAT1 binding to the GAS element of the IRF-1 promoter region.
GAS Binding (binding) of STAT1
3) Confidence 0.03 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.03 Pain Relevance 0.07

General Comments

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