INT186355

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.00
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a, Il17a) extracellular region (Il23a, Il17a)
Anatomy Link Frequency
ear 2
T cells 2
neutrophils 2
Il23a (Mus musculus)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 176 100.00 Very High Very High Very High
rheumatoid arthritis 192 97.20 Very High Very High Very High
Arthritis 114 94.80 High High
psoriasis 44 84.40 Quite High
Inflammation 90 81.60 Quite High
antagonist 5 80.44 Quite High
Inflammatory mediators 4 60.08 Quite High
chemokine 41 50.00 Quite Low
Inflammatory response 4 15.52 Low Low
Multiple sclerosis 48 7.76 Low Low
Disease Link Frequency Relevance Heat
Infection 198 99.68 Very High Very High Very High
Cold Sores 214 98.24 Very High Very High Very High
Rheumatoid Arthritis 193 97.20 Very High Very High Very High
Experimental Arthritis 7 94.80 High High
Pressure And Volume Under Development 2 91.36 High High
Targeted Disruption 8 87.88 High High
Psoriasis 49 84.40 Quite High
Acanthosis 4 83.36 Quite High
Multiple Sclerosis 64 82.40 Quite High
INFLAMMATION 91 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CD4+ T cells from naïve and collagen-type II immunized DBA/1 mice, IL-23 increased the expression of IL-17A, IL-17F, and RORgammat.
IL-23 Positive_regulation (increased) of Gene_expression (expression) of IL-17A in T cells
1) Confidence 0.12 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.49 Pain Relevance 0.10
When injected into mouse ear, IL-23 induced the production of both IL-22 and IL-17, as shown by reverse transcriptase polymerase chain reaction (RT-PCR) analysis.
IL-23 Positive_regulation (induced) of Gene_expression (production) of IL-17 in ear
2) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.29 Pain Relevance 0.44
In the mouse, at least, IL-23 is a key cytokine for the induction of the Th17 pathway and production of IL-17 [16].
IL-23 Positive_regulation (cytokine) of Gene_expression (production) of IL-17 associated with cytokine
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582809 Disease Relevance 0.84 Pain Relevance 0.52
IL-23 drives IL-17 production of NK cells, which mobilizes neutrophils and promotes production of the proinflammatory cytokines IL-1, IL-6, and TNF [261].
IL-23 Positive_regulation (drives) of Gene_expression (production) of IL-17 in neutrophils associated with cytokine
4) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.38 Pain Relevance 0.19

General Comments

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