INT18636

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Context Info
Confidence 0.37
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.05
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hip 1
cartilage 1
OAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 244 100.00 Very High Very High Very High
Inflammation 79 99.98 Very High Very High Very High
Clonidine 2 87.84 High High
imagery 16 82.36 Quite High
dexamethasone 14 76.08 Quite High
antagonist 4 74.92 Quite High
agonist 26 74.28 Quite High
cytokine 87 70.84 Quite High
rheumatoid arthritis 8 70.24 Quite High
Pain 57 56.80 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 177 100.00 Very High Very High Very High
Hip Osteoarthritis 45 100.00 Very High Very High Very High
Frailty 33 100.00 Very High Very High Very High
INFLAMMATION 81 99.98 Very High Very High Very High
Disease 57 98.72 Very High Very High Very High
Inflammatory Bowel Disease 64 97.60 Very High Very High Very High
Overweight 20 95.92 Very High Very High Very High
Obesity 52 95.48 Very High Very High Very High
Adhesions 4 92.04 High High
Rheumatoid Arthritis 8 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prazosin at 0.5 microM did not affect the amplitudes of OAP by itself, but abolished both the inhibitory effect of PE on AS-induced OAP and the stimulatory effect of PE on high Ca2(+)-induced OAP.
Negative_regulation (effect) of OAP
1) Confidence 0.37 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.16
Prazosin at 0.5 microM did not affect the amplitudes of OAP by itself, but abolished both the inhibitory effect of PE on AS-induced OAP and the stimulatory effect of PE on high Ca2(+)-induced OAP.
Neg (not) Negative_regulation (abolished) of OAP
2) Confidence 0.37 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.19
While having hip OA could lead to obesity, and while overweight and hip OA may not be related and hip OA may not occur in all populations to the same extent [14,17], it is possible that cumulative exposure to excessive body mass may increase the risk of subsequently developing hip OA [1,2] and the worsening of the disease [11,12,15,18].
Negative_regulation (developing) of OA in hip associated with obesity, disease, osteoarthritis and overweight
3) Confidence 0.34 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.62 Pain Relevance 0.43
Participant characteristics (eg; gender, radiographic severity of TFJ and PFJ OA) will also be included as covariates.
Negative_regulation (severity) of PFJ OA associated with osteoarthritis
4) Confidence 0.27 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2556332 Disease Relevance 0.35 Pain Relevance 0.17
Since two theories (OS and OA) and their possible correspondence have to be introduced in the restricted space of an article, only the essential outlines of OS are shown here.
Negative_regulation (introduced) of OA
5) Confidence 0.16 Published 2010 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2948146 Disease Relevance 0 Pain Relevance 0
Nonetheless, our findings indicate that assessing whether inflammation precedes clinical OA merits specific investigation.
Negative_regulation (precedes) of OA associated with inflammation and osteoarthritis
6) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.34 Pain Relevance 0.52
Cells cultured with ARA showed in particular an increase in the proportion of long chain n-6 PUFAs (mainly ARA) and a decrease in n-9 MUFAs (mainly OA) as compared with cells cultured with only OA.
Negative_regulation (decrease) of OA
7) Confidence 0.05 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.06 Pain Relevance 0.09
Moreover, colonic arachidonic acid (ARA) proportions are increased and oleic acid (OA) proportions are decreased.
Negative_regulation (decreased) of OA
8) Confidence 0.05 Published 2007 Journal Lipids Section Abstract Doc Link PMC2039812 Disease Relevance 0.46 Pain Relevance 0.20
A mixture of cell populations will be present in OA cartilage.
Negative_regulation (present) of OA in cartilage associated with osteoarthritis
9) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.22 Pain Relevance 0.38

General Comments

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