INT186373

Context Info Confidence 0.14 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.52 Pain Relevance 0.42

extracellular space (Il6, Il17a) extracellular region (Il6, Il17a)

Anatomy Link Frequency neutrophils 2 Il6 (Mus musculus) Il17a (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 89 100.00 Inflammation 16 95.32 antagonist 1 79.92 Inflammatory response 5 24.24 Central nervous system 7 5.00 anesthesia 2 5.00 Potency 2 5.00 ketamine 1 5.00 alcohol 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Infection 321 99.84 Cold Sores 214 97.72 Sprains And Strains 84 96.16 INFLAMMATION 21 95.32 Septic Shock 1 65.68 Death 17 63.84 Convalescence 9 54.40 Apoptosis 11 53.16 Viral Infection 15 40.72 Francisella Infection 28 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

and IL-6, the production of IL-17A could not be further induced by infection doses beyond 10×LD50.

IL-6 Neg (not) Positive_regulation (induced) of Gene_expression (production) of IL-17A associated with infection

1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.14 Pain Relevance 0.20

IL-23 drives IL-17 production of NK cells, which mobilizes neutrophils and promotes production of the proinflammatory cytokines IL-1, IL-6, and TNF [261].

IL-6 Positive_regulation (cytokines) of Gene_expression (production) of IL-17 in neutrophils associated with cytokine

2) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.38 Pain Relevance 0.22

General Comments

This test has worked.