INT186373

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.52
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il17a) extracellular region (Il6, Il17a)
Anatomy Link Frequency
neutrophils 2
Il6 (Mus musculus)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 89 100.00 Very High Very High Very High
Inflammation 16 95.32 Very High Very High Very High
antagonist 1 79.92 Quite High
Inflammatory response 5 24.24 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 321 99.84 Very High Very High Very High
Cold Sores 214 97.72 Very High Very High Very High
Sprains And Strains 84 96.16 Very High Very High Very High
INFLAMMATION 21 95.32 Very High Very High Very High
Septic Shock 1 65.68 Quite High
Death 17 63.84 Quite High
Convalescence 9 54.40 Quite High
Apoptosis 11 53.16 Quite High
Viral Infection 15 40.72 Quite Low
Francisella Infection 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and IL-6, the production of IL-17A could not be further induced by infection doses beyond 10√óLD50.


IL-6 Neg (not) Positive_regulation (induced) of Gene_expression (production) of IL-17A associated with infection
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.14 Pain Relevance 0.20
IL-23 drives IL-17 production of NK cells, which mobilizes neutrophils and promotes production of the proinflammatory cytokines IL-1, IL-6, and TNF [261].
IL-6 Positive_regulation (cytokines) of Gene_expression (production) of IL-17 in neutrophils associated with cytokine
2) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.38 Pain Relevance 0.22

General Comments

This test has worked.

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