INT186385

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.24
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF) extracellular matrix organization (TNF) cell proliferation (Tnfrsf1b)
extracellular space (TNF) signal transduction (TNF) extracellular region (TNF)
Anatomy Link Frequency
neuronal 1
TNF (Homo sapiens)
Tnfrsf1b (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 95.44 Very High Very High Very High
Central nervous system 24 93.68 High High
Inflammation 64 85.92 High High
Bioavailability 62 77.84 Quite High
Etanercept 21 61.52 Quite High
Infliximab 24 60.92 Quite High
chemokine 10 59.16 Quite High
cytokine 138 50.00 Quite Low
Inflammatory response 6 44.64 Quite Low
rheumatoid arthritis 7 36.32 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 23 98.56 Very High Very High Very High
Granuloma 46 98.50 Very High Very High Very High
Cancer 24 98.20 Very High Very High Very High
Death 31 94.96 High High
Apoptosis 71 92.24 High High
Infection 549 89.12 High High
Cold Sores 428 87.60 High High
INFLAMMATION 72 85.92 High High
Mycobacterial Infection 132 80.32 Quite High
Immune System Diseases 2 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNFR2 is restricted to expression in endothelial, hematopoetic, and some neuronal populations and displays preferential binding to tmTNF, both of these characteristic are likely to result in fewer biological effects compared to those mediated by TNFR1-dependent signaling [16].
tmTNF Binding (binding) of TNFR2 in neuronal
1) Confidence 0.30 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.73 Pain Relevance 0.09
Both forms of TNF function by binding to one of two receptors, TNFR1 (TNFRp55) and TNFR2 (TNFRp75) [13].
TNF Binding (binding) of TNFR2
2) Confidence 0.26 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.14 Pain Relevance 0.18
In contrast, under situations where TNF is released from the receptor fusion molecule and there are high numbers of cell associated TNF receptors present (such as in a granuloma) and possibly a lower level of receptor fusion (due to poor penetration), TNF might bind to the cell-associated TNFR1 or TNFR2 instead of back onto the receptor fusion.
TNF Spec (might) Binding (bind) of TNFR2 associated with granuloma
3) Confidence 0.20 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.42 Pain Relevance 0.15
Both membrane bound and soluble TNF interact as homotrimers with two different receptors, the p55 TNFR1 (TNFRSF1A) and the p75 TNFR2 (TNFRSF1B) [222].
TNF Binding (interact) of TNFR2
4) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.48 Pain Relevance 0
Both membrane bound and soluble TNF interact as homotrimers with two different receptors, the p55 TNFR1 (TNFRSF1A) and the p75 TNFR2 (TNFRSF1B) [222].
TNF Binding (interact) of TNFRSF1B
5) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.48 Pain Relevance 0

General Comments

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