INT18639

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 10.49
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chondrocyte 2
body 2
joints 1
hip 1
cartilage 1
OAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 559 100.00 Very High Very High Very High
antagonist 8 97.84 Very High Very High Very High
Pain 22 94.60 High High
Clonidine 4 87.84 High High
Inflammation 123 87.40 High High
Arthritis 16 87.04 High High
agonist 28 86.24 High High
corticosteroid 4 85.68 High High
imagery 15 85.36 High High
cytokine 103 81.92 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 451 100.00 Very High Very High Very High
Hip Osteoarthritis 135 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 43 99.96 Very High Very High Very High
Obesity 94 99.84 Very High Very High Very High
Disease 129 99.48 Very High Very High Very High
Overweight 60 99.08 Very High Very High Very High
Aging 56 97.44 Very High Very High Very High
Death 9 96.84 Very High Very High Very High
Stress 1 95.92 Very High Very High Very High
Pain 18 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, specific alpha 1-adrenergic actions of phenylephrine may exert either pro-arrhythmic or antiarrhythmic effects on OAP and triggered activity depending on the method of induction of OAP.
Positive_regulation (induction) of OAP
1) Confidence 0.69 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.13
Prazosin at 0.5 microM did not affect the amplitudes of OAP by itself, but abolished both the inhibitory effect of PE on AS-induced OAP and the stimulatory effect of PE on high Ca2(+)-induced OAP.
Positive_regulation (induced) of OAP
2) Confidence 0.60 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.18
While having hip OA could lead to obesity, and while overweight and hip OA may not be related and hip OA may not occur in all populations to the same extent [14,17], it is possible that cumulative exposure to excessive body mass may increase the risk of subsequently developing hip OA [1,2] and the worsening of the disease [11,12,15,18].
Positive_regulation (lead) of OA in body associated with obesity, disease, osteoarthritis and overweight
3) Confidence 0.43 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.74 Pain Relevance 0.48
Prazosin at 0.5 microM did not affect the amplitudes of OAP by itself, but abolished both the inhibitory effect of PE on AS-induced OAP and the stimulatory effect of PE on high Ca2(+)-induced OAP.
Positive_regulation (induced) of OAP
4) Confidence 0.40 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.16
Phenylephrine (PE, 0.5 to 10 microM) increased the amplitude of OAP and induced triggered activity when subthreshold OAP were caused by high Ca2+.
Positive_regulation (increased) of OAP
5) Confidence 0.40 Published 1990 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1977923 Disease Relevance 0 Pain Relevance 0.14
Moreover, we cannot determine whether a subsequently increased BMI is more important than other factors in increasing the risk of hip OA.
Positive_regulation (increasing) of OA in hip associated with osteoarthritis
6) Confidence 0.40 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.11 Pain Relevance 0.40
However, studies of the effects of body mass on avian degenerative joint disease, which shares common pathologies with human degenerative disease, have clearly shown that OA can be mediated by body mass [24].
Positive_regulation (mediated) of OA in body associated with disease and osteoarthritis
7) Confidence 0.40 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.12 Pain Relevance 0.39
Ultimately, the texture analysis will be able to provide an alternative OA scoring method, which can potentially reflect the progression of the disease in a more direct fashion compared to the existing clinically utilized classification schemes based on radiology.
Positive_regulation (provide) of OA associated with disease and osteoarthritis
8) Confidence 0.31 Published 2010 Journal J: Section Abstract Doc Link PMC2909716 Disease Relevance 0.72 Pain Relevance 0.31
Therefore, and because of differences in ability to compete with ARA for incorporation in tissue phospholipids [10, 11], it is probably easier to lower mucosal ARA levels by increasing fish oil intake than by increasing OA intake.
Positive_regulation (increasing) of OA
9) Confidence 0.09 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.87 Pain Relevance 0.14
Since OA is already the most abundant fatty acid present in our diet [9] and in the colon mucosa [4], decreasing mucosal ARA levels may be easier by increasing fish oil intake than by increasing OA intake.
Positive_regulation (increasing) of OA in colon
10) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.43 Pain Relevance 0.14
Among genes induced in larvae by copper exposure, we detected strong stimulation of the mmp9 gene (VEG, OAP and MLA, unpublished work).
Positive_regulation (stimulation) of OAP
11) Confidence 0.04 Published 2010 Journal BMC Biol Section Body Doc Link PMC3022775 Disease Relevance 0.56 Pain Relevance 0.11
Series 2 – Resolving OA induced ALI
Positive_regulation (induced) of OA associated with adult respiratory distress syndrome
12) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.39 Pain Relevance 0.07
As a result, the ratio of ALK1/ALK5 expressing cells strongly increased in OA articular chondrocytes.
Positive_regulation (increased) of OA in chondrocytes associated with osteoarthritis
13) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.87 Pain Relevance 0.26
This indicates not only that the levels of IL-1 are increased in OA joints, but also that OA chondrocytes are more sensitive to IL-1.
Positive_regulation (increased) of OA in joints associated with osteoarthritis
14) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.86 Pain Relevance 0.65
The synthesis of the main structural component of cartilage, type II collagen, is clearly enhanced in OA cartilage [11,12].
Positive_regulation (enhanced) of OA in cartilage associated with osteoarthritis
15) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.02 Pain Relevance 0.69
signaling apparently results in aberrations in chondrocyte differentiation and enhanced OA development.
Positive_regulation (enhanced) of OA in chondrocyte associated with osteoarthritis
16) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.79 Pain Relevance 0.33

General Comments

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