INT186393

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.55
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Tnfrsf1a) extracellular space (TNF, Tnfrsf1a) extracellular region (TNF, Tnfrsf1a)
plasma membrane (TNF, Tnfrsf1a) nucleus (Tnfrsf1a) intracellular (TNF)
TNF (Homo sapiens)
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 31 98.48 Very High Very High Very High
metalloproteinase 6 95.44 Very High Very High Very High
Inflammation 151 94.64 High High
Inflammatory response 8 87.44 High High
Bioavailability 155 77.12 Quite High
addiction 8 70.88 Quite High
cytokine 195 62.56 Quite High
Etanercept 44 61.52 Quite High
Infliximab 55 60.92 Quite High
chemokine 29 59.16 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 132 100.00 Very High Very High Very High
Cancer 42 100.00 Very High Very High Very High
Necrosis 40 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 65 99.62 Very High Very High Very High
Stress 11 98.68 Very High Very High Very High
Granuloma 115 98.50 Very High Very High Very High
INFLAMMATION 165 98.00 Very High Very High Very High
Lymphedema 45 96.24 Very High Very High Very High
Disease 161 95.60 Very High Very High Very High
Death 59 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both forms of TNF function by binding to one of two receptors, TNFR1 (TNFRp55) and TNFR2 (TNFRp75) [13].
TNF Binding (binding) of TNFRp55
1) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.14 Pain Relevance 0.18
TNF can also induce apoptosis by binding to the TNFR1 receptor.
TNF Binding (binding) of TNFR1 associated with apoptosis
2) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.41 Pain Relevance 0.06
Both forms of TNF function by binding to one of two receptors, TNFR1 (TNFRp55) and TNFR2 (TNFRp75) [13].
TNF Binding (binding) of TNFRp75
3) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.14 Pain Relevance 0.18
Both forms of TNF function by binding to one of two receptors, TNFR1 (TNFRp55) and TNFR2 (TNFRp75) [13].
TNF Binding (binding) of TNFR1
4) Confidence 0.37 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 1.14 Pain Relevance 0.18
In contrast, under situations where TNF is released from the receptor fusion molecule and there are high numbers of cell associated TNF receptors present (such as in a granuloma) and possibly a lower level of receptor fusion (due to poor penetration), TNF might bind to the cell-associated TNFR1 or TNFR2 instead of back onto the receptor fusion.
TNF Spec (might) Binding (bind) of TNFR1 associated with granuloma
5) Confidence 0.29 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.42 Pain Relevance 0.15
In addition to TNFR1-induced activation of stress-induced kinase signaling in contributing to apoptotic signaling, TNFR1 can be internalized after TNF binding and this leads to dissociation of the TRADD/TRAF2/RIP complex and association of Fas-associated DD (FADD), recruitment of pro-caspase 8, and formation of the death-inducing signaling complex (DISC), triggering activation of the executioner caspases through the extrinsic apoptosis pathway [34,35].
TNF Binding (binding) of TNFR1 associated with stress, apoptosis and death
6) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 1.16 Pain Relevance 0.07
Both membrane bound and soluble TNF interact as homotrimers with two different receptors, the p55 TNFR1 (TNFRSF1A) and the p75 TNFR2 (TNFRSF1B) [222].
TNF Binding (interact) of TNFRSF1A
7) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.47 Pain Relevance 0
Both membrane bound and soluble TNF interact as homotrimers with two different receptors, the p55 TNFR1 (TNFRSF1A) and the p75 TNFR2 (TNFRSF1B) [222].
TNF Binding (interact) of TNFR1
8) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.47 Pain Relevance 0
TNF binding studies in cells and in vitro have demonstrated that the TRAPS-associated mutant TNFR1 is unable to bind to TNF.
TNF Neg (unable) Binding (bind) of TNFR1 associated with tumor necrosis factor receptor-associated periodic syndrome
9) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.88 Pain Relevance 0.07
receptor (sTNF-R1) upon tumor necrosis factor (TNF)-?
tumor necrosis factor Binding (receptor) of sTNF-R1 associated with necrosis and cancer
10) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2791214 Disease Relevance 1.32 Pain Relevance 0.40

General Comments

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