INT1864

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1975
Last Reported 2008
Negated 5
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 6.18
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) extracellular region (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 7
brain 2
neuronal 1
spinal 1
nerve 1
Bche (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 100.00 Very High Very High Very High
anesthesia 15 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Abeta 3 100.00 Very High Very High Very High
halothane 3 100.00 Very High Very High Very High
Catecholamine 3 100.00 Very High Very High Very High
antiallodynic 2 99.98 Very High Very High Very High
Pain 8 99.92 Very High Very High Very High
Antinociceptive 3 99.08 Very High Very High Very High
allodynia 4 94.72 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 100.00 Very High Very High Very High
Targeted Disruption 64 99.16 Very High Very High Very High
Disease 226 98.74 Very High Very High Very High
Aging 8 98.16 Very High Very High Very High
Dementia 10 96.04 Very High Very High Very High
Cognitive Disorder 68 95.20 Very High Very High Very High
Neuropathic Pain 5 94.72 High High
Apnoea 4 94.28 High High
Alzheimer's Dementia 13 91.92 High High
Pain 5 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Edrophonium did not affect plasma cholinesterase activity.
Neg (not) Regulation (affect) of plasma cholinesterase in plasma
1) Confidence 0.47 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7486038 Disease Relevance 0 Pain Relevance 0.19
The purpose of the present studies was to determine both the antinociceptive effects in normal mice and the antiallodynic effects in PTX-treated mice of systemically administered muscarinic cholinergic receptor agonists and cholinesterase inhibitors.
Regulation (effects) of cholinesterase associated with agonist, antiallodynic and antinociceptive
2) Confidence 0.40 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10974334 Disease Relevance 0.33 Pain Relevance 0.73
The effect of quinidine at therapeutic and subtherapeutic concentrations on pseudocholinesterase activity in the plasma of 16 normal pregnant women was studied.
Regulation (effect) of pseudocholinesterase in plasma
3) Confidence 0.27 Published 1987 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3674164 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Measurements of quantitative alterations of serum pseudocholinesterase levels may be useful in the treatment of patients with chronic spinal pain.


Regulation (alterations) of serum pseudocholinesterase in spinal
4) Confidence 0.26 Published 2000 Journal Spine Section Body Doc Link 10908934 Disease Relevance 0 Pain Relevance 0
In addition to a pseudo-irreversible inhibition, rivastigmine also affects the activity of butyrylcholinesterase (BchE) (Xie et al 2000), which forms up to 10% of the cholinesterase in the human brain.
Regulation (affects) of butyrylcholinesterase in brain
5) Confidence 0.26 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761169 Disease Relevance 0.49 Pain Relevance 0.05
In addition to a pseudo-irreversible inhibition, rivastigmine also affects the activity of butyrylcholinesterase (BchE) (Xie et al 2000), which forms up to 10% of the cholinesterase in the human brain.
Regulation (affects) of BchE in brain
6) Confidence 0.26 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761169 Disease Relevance 0.49 Pain Relevance 0.05
The effects of histamine H2-receptor antagonists on acetylcholinesterase and pseudocholinesterase activity were studied.
Regulation (effects) of pseudocholinesterase associated with antagonist
7) Confidence 0.25 Published 1986 Journal Gastroenterol. Jpn. Section Abstract Doc Link 2874096 Disease Relevance 0 Pain Relevance 0.25
Effect of suxamethonium, pancuronium, neostigmine and halothane on serum cholinesterase activity.
Regulation (Effect) of serum cholinesterase associated with halothane
8) Confidence 0.21 Published 1989 Journal Middle East J Anesthesiol Section Title Doc Link 2637954 Disease Relevance 0 Pain Relevance 0.23
Aging and its variants, such as AD, should be viewed as the result of multiple "hits," including alterations in the levels of Abeta, metals, cholinesterase enzymes, and neuronal gene expression.
Regulation (alterations) of cholinesterase in neuronal associated with aging, disease and abeta
9) Confidence 0.18 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16387707 Disease Relevance 1.40 Pain Relevance 0.13
Rivastigmine (Novartis Pharmaceuticals Corporation, NJ, USA) is a dual acting inhibitor that targets both acetylcholinesterase and butyrylcholinesterase.
Regulation (targets) of butyrylcholinesterase
10) Confidence 0.17 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 1.49 Pain Relevance 0
No correlation was found between the changes in serum potassium following suxamethonium and either the serum cholinesterase activity or the changes in Pco2 and pH.
Regulation (changes) of serum cholinesterase
11) Confidence 0.17 Published 1975 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 242180 Disease Relevance 0.75 Pain Relevance 0.08
The importance of serum cholinesterase activity in burned patients was evaluated in relation to anaesthesia.
Regulation (importance) of serum cholinesterase
12) Confidence 0.17 Published 1975 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 242180 Disease Relevance 0.30 Pain Relevance 0
Since the endogenous mouse BChE activity in the milk of non-transgenic mice is minimal [14], it is reasonable that no change of residual BChE activity in the non-transgenic milk was detected despite the addition of nerve agents with increased concentrations (Fig. 3B).


Neg (no) Regulation (change) of BChE in nerve associated with targeted disruption
13) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.58 Pain Relevance 0
Administration of vecuronium did not cause significant changes in blood pressure, pulse rate, or plasma cholinesterase activity.
Neg (not) Regulation (changes) of plasma cholinesterase in plasma associated with cv unclassified under development
14) Confidence 0.12 Published 1983 Journal Anesth. Analg. Section Abstract Doc Link 6137170 Disease Relevance 0.10 Pain Relevance 0.08
Vecuronium may be advantageous in parturients undergoing cesarean section under general anesthesia because it maintains cardiovascular stability, is noncumulative, is readily antagonized by neostigmine, has no effect on the plasma cholinesterase activity, and has no deleterious effect on the newborn.
Neg (no) Regulation (effect) of plasma cholinesterase in plasma associated with anesthesia
15) Confidence 0.12 Published 1983 Journal Anesth. Analg. Section Abstract Doc Link 6137170 Disease Relevance 0.06 Pain Relevance 0.10
During the infusion, succinylcholine requirements increased in every patient (tachyphylaxis), but there was no significant change in plasma cholinesterase activity.
Neg (no) Regulation (change) of plasma cholinesterase in plasma
16) Confidence 0.10 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 7137612 Disease Relevance 0 Pain Relevance 0.12
The influence of catecholamines on pseudocholinesterase enzymatic activity.
Regulation (influence) of pseudocholinesterase associated with pain and catecholamine
17) Confidence 0.05 Published 2006 Journal J Clin Monit Comput Section Title Doc Link 16953463 Disease Relevance 0.18 Pain Relevance 0.33
The effect of reduced plasma cholinesterase (ChE) activity in response to normothermic cardiopulmonary bypass (CPB) on mivacurium neuromuscular block was studied in nine patients anesthetized with propofol/fentanyl.
Regulation (effect) of plasma cholinesterase in plasma
18) Confidence 0.01 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7762834 Disease Relevance 0 Pain Relevance 0
Changes in plasma cholinesterase activity and mivacurium neuromuscular block in response to normothermic cardiopulmonary bypass.
Regulation (Changes) of plasma cholinesterase in plasma associated with anesthesia
19) Confidence 0.01 Published 1995 Journal Anesth. Analg. Section Title Doc Link 7762834 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox