INT186421

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.26
Pain Relevance 4.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rorb) cellular_component (Rorb)
Anatomy Link Frequency
spinal 4
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 68 99.78 Very High Very High Very High
nMDA receptor 95 99.76 Very High Very High Very High
qutenza 87 99.48 Very High Very High Very High
intrathecal 28 99.42 Very High Very High Very High
Kinase C 54 98.48 Very High Very High Very High
Glutamate receptor 28 97.76 Very High Very High Very High
Dorsal horn 5 94.28 High High
antagonist 14 94.12 High High
agonist 14 93.48 High High
central sensitization 43 92.92 High High
Disease Link Frequency Relevance Heat
Nociception 71 96.76 Very High Very High Very High
Overdose 5 90.00 High High
Hypersensitivity 5 87.12 High High
Hyperalgesia 16 84.64 Quite High
Vibrio Infection 40 83.84 Quite High
Cognitive Disorder 94 69.04 Quite High
Decapitation 3 59.28 Quite High
Injury 19 40.24 Quite Low
Pain 6 18.40 Low Low
INFLAMMATION 3 17.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of studies have shown that enhanced phosphorylation of CREB transcription factor could account for the potential contribution to long-term changes in the spinal processing of nociceptive information [6,13].
Positive_regulation (account) of Phosphorylation (phosphorylation) of transcription factor in spinal associated with nociception
1) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.10 Pain Relevance 0.73
A number of studies have shown that enhanced phosphorylation of CREB transcription factor could account for the potential contribution to long-term changes in the spinal processing of nociceptive information [6,13].
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of transcription factor in spinal associated with nociception
2) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.10 Pain Relevance 0.73
Our study further demonstrates the roles of PKA and PKC in molecular mechanism of regulation of gene transcription in response to capsaicin injection, in which they mediate the phosphorylation of the transcription factor, CREB.
Positive_regulation (mediate) of Phosphorylation (phosphorylation) of transcription factor associated with kinase c and qutenza
3) Confidence 0.04 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.23 Pain Relevance 0.99
We further demonstrate that intrathecal injection of SP-CTA in rats induces the phosphorylation of the transcription factor cyclic AMP response element binding protein (CREB) and also enhances the expression of the immediate early gene c-Fos.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of transcription factor associated with intrathecal
4) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1878491 Disease Relevance 0.38 Pain Relevance 0.48
We chose to examine CREB because elevated levels of cAMP lead to the phosphorylation of this transcription factor [26].
Positive_regulation (lead) of Phosphorylation (phosphorylation) of transcription factor
5) Confidence 0.02 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1878491 Disease Relevance 0.26 Pain Relevance 0.30
In the present study we show that NMDA receptor activation induces postnatal Müller glia-derived retinal cell progenitor proliferation and transcription factor CREB phosphorylation both in culture and in vivo.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of transcription factor associated with nmda receptor
6) Confidence 0.01 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2666774 Disease Relevance 0 Pain Relevance 0.35
In the present study, we show that NMDA receptor activation induces postnatal Müller glia-derived retinal cell progenitor proliferation and transcription factor CREB phosphorylation both in culture and in vivo.


Positive_regulation (induces) of Phosphorylation (phosphorylation) of transcription factor associated with nmda receptor
7) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.06 Pain Relevance 0.34
NMDA receptor activation induces transcription factor CREB phosphorylation in cultured Müller-derived progenitor cells.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of transcription factor associated with nmda receptor
8) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0 Pain Relevance 0.40
But cGMP as well as cAMP are involved in postsynaptic L-LTP processes resulting in phosphorylation of the transcription factor CREB eventually.
Positive_regulation (resulting) of Phosphorylation (phosphorylation) of transcription factor associated with long-term potentiation
9) Confidence 0.01 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2704616 Disease Relevance 0.13 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox