INT186433

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.03
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3, Creb1) nucleus (Trib3, Creb1) nucleoplasm (Creb1)
mitochondrion (Creb1) DNA binding (Creb1) enzyme binding (Trib3)
Anatomy Link Frequency
spinal cord 2
dorsal horn 2
Trib3 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 36 100.00 Very High Very High Very High
Dorsal horn 2 99.42 Very High Very High Very High
Spinal cord 30 99.40 Very High Very High Very High
qutenza 58 97.82 Very High Very High Very High
long-term potentiation 10 96.52 Very High Very High Very High
central sensitization 26 94.48 High High
intrathecal 12 77.96 Quite High
spinothalamic 6 69.08 Quite High
Pain 10 56.48 Quite High
c fibre 2 36.80 Quite Low
Disease Link Frequency Relevance Heat
Nociception 34 84.08 Quite High
Hypersensitivity 2 68.80 Quite High
Pain 4 56.48 Quite High
Injury 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major findings in the current study demonstrated that intradermal capsaicin injection causes an increase in Ser-133 CREB phosphorylation in the dorsal horn and that the enhancement of CREB phosphorylation is regulated by the activity of MAP kinase, PKA and PKC.
kinase Regulation (regulated) of Phosphorylation (phosphorylation) of CREB in dorsal horn associated with kinase c, qutenza and dorsal horn
1) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.08 Pain Relevance 0.79
In summary, the findings from our investigation provide strong evidence that MAP kinase, PKA and PKC participate in the regulation of CREB phosphorylation status in the spinal cord following peripheral noxious stimulation.
kinase Regulation (regulation) of Phosphorylation (phosphorylation) of CREB in spinal cord associated with kinase c and spinal cord
2) Confidence 0.03 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.23 Pain Relevance 0.92

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox