INT186435

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkcg, Creb1) nucleoplasm (Creb1) mitochondrion (Creb1)
intracellular (Prkcg) DNA binding (Creb1) response to stress (Prkcg)
Anatomy Link Frequency
spinal cord 1
Prkcg (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 36 100.00 Very High Very High Very High
Spinal cord 30 98.76 Very High Very High Very High
long-term potentiation 10 95.88 Very High Very High Very High
qutenza 58 94.56 High High
central sensitization 26 93.84 High High
spinothalamic 6 83.00 Quite High
Pain 10 55.20 Quite High
c fibre 2 50.72 Quite High
anesthesia 2 35.04 Quite Low
intrathecal 12 30.00 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 2 82.72 Quite High
Nociception 34 71.44 Quite High
Pain 4 55.20 Quite High
INFLAMMATION 2 12.72 Low Low
Nervous System Injury 2 10.76 Low Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, as important regulators, both PKA and PKC actively contribute to the activity-dependent hippocampal synaptic plasticity by regulating CREB-dependent target genes.
PKC Regulation (regulating) of CREB-dependent associated with kinase c
1) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.22 Pain Relevance 0.99
In summary, the findings from our investigation provide strong evidence that MAP kinase, PKA and PKC participate in the regulation of CREB phosphorylation status in the spinal cord following peripheral noxious stimulation.
PKC Regulation (regulation) of CREB in spinal cord associated with kinase c and spinal cord
2) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.23 Pain Relevance 0.91

General Comments

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