INT186439

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaca, Creb1) mitochondrion (Prkaca, Creb1) nucleus (Prkaca, Creb1)
Golgi apparatus (Prkaca) DNA binding (Creb1) protein complex (Prkaca)
Anatomy Link Frequency
dorsal horn 2
Prkaca (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 18 99.80 Very High Very High Very High
Dorsal horn 1 99.42 Very High Very High Very High
qutenza 29 97.82 Very High Very High Very High
intrathecal 6 77.96 Quite High
Spinal cord 15 50.00 Quite Low
central sensitization 13 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
spinothalamic 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 17 84.48 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major findings in the current study demonstrated that intradermal capsaicin injection causes an increase in Ser-133 CREB phosphorylation in the dorsal horn and that the enhancement of CREB phosphorylation is regulated by the activity of MAP kinase, PKA and PKC.
PKA Regulation (regulated) of Phosphorylation (phosphorylation) of CREB in dorsal horn associated with kinase c, qutenza and dorsal horn
1) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.08 Pain Relevance 0.79

General Comments

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