INT18644

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Context Info
Confidence 0.31
First Reported 1984
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 1.22
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OXT) extracellular space (OXT) extracellular region (OXT)
response to stress (OXT) cytoplasm (OXT)
Anatomy Link Frequency
myometrium 2
telomere 1
OXT (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 5 99.44 Very High Very High Very High
antagonist 12 88.68 High High
Dismenorea 36 80.72 Quite High
agonist 2 58.08 Quite High
Potency 7 43.68 Quite Low
amygdala 10 34.88 Quite Low
Dopamine 10 32.84 Quite Low
Enkephalin 1 25.00 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Anterior cingulate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mental Disorders 5 99.62 Very High Very High Very High
Alcohol Addiction 5 99.44 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 5 92.80 High High
Reprotox - General 1 5 89.20 High High
Dysmenorrhea 36 80.72 Quite High
Amnesia 5 80.36 Quite High
Respiratory Distress 2 76.84 Quite High
Premature Birth 1 72.72 Quite High
Anxiety Disorder 10 57.16 Quite High
Intellectual Impairment 1 48.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This myometrial PGF2 alpha binding capacity was approximately 1/20 to 1/30 that of the OXT binding, while binding affinity was almost equal.
OXT Binding (binding) of
1) Confidence 0.31 Published 1984 Journal Endocrinol. Jpn. Section Abstract Doc Link 6097443 Disease Relevance 0.08 Pain Relevance 0.08
Among the components, the OXT binding increased only in the myometrium during pregnancy, suggesting this tissue specifically responds to OXT.
OXT Binding (binding) of in myometrium
2) Confidence 0.31 Published 1984 Journal Endocrinol. Jpn. Section Abstract Doc Link 6097443 Disease Relevance 0.06 Pain Relevance 0.06
Human myometrium during pregnancy contains and responds to V1 vasopressin receptors as well as oxytocin receptors.
oxytocin Binding (responds) of in myometrium
3) Confidence 0.30 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2156888 Disease Relevance 0 Pain Relevance 0.10
Using multilocus linkage analysis, the ARVP/OT loci map to the distal short arm of chromosome 20 about 15 centimorgans toward the telomere from the D20S5 locus, which is located near the middle of the short arm at 20p 12.21.
OT Binding (map) of in telomere
4) Confidence 0.30 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 1978246 Disease Relevance 0 Pain Relevance 0
A least squares regression of generosity in the UG, controlling for the amount of altruism participants revealed in the dictator game, and a binary OT indicator showed that OT continues to be significantly associated with generosity (OT coeff. 0.648, two-tailed t-test p?
OT Binding (associated) of
5) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0
Exclusion criteria included significant medical or psychiatric illness, medications that interact with OT, and drug or alcohol abuse.
OT Binding (interact) of associated with mental disorders and alcohol
6) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.35 Pain Relevance 0.05
A total of 68 males participated in the experiment with 34 of them receiving OT and 34 receiving placebo.
OT Binding (receiving) of
7) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.36 Pain Relevance 0.03
Aggregating the OT and placebo treatments, the average minimum acceptable offer was $2.97.
OT Binding (Aggregating) of
8) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0.09 Pain Relevance 0
A least squares regression of generosity in the UG, controlling for the amount of altruism participants revealed in the dictator game, and a binary OT indicator showed that OT continues to be significantly associated with generosity (OT coeff. 0.648, two-tailed t-test p?
OT Binding (indicator) of
9) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2040517 Disease Relevance 0 Pain Relevance 0
Barusiban has approximately 300-fold greater affinity for the human cloned OT receptor than for the V1A receptor, whereas atosiban binds well to both receptors.
OT Binding (binds) of
10) Confidence 0.16 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892056 Disease Relevance 0.28 Pain Relevance 0.24

General Comments

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