INT186440

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Creb1, Jun) DNA binding (Creb1, Jun) transcription factor binding (Creb1, Jun)
cytosol (Jun) nucleoplasm (Creb1) mitochondrion (Creb1)
Creb1 (Rattus norvegicus)
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
central sensitization 13 84.56 Quite High
Dynorphin 2 83.60 Quite High
Enkephalin 2 82.72 Quite High
Glutamate receptor 3 82.20 Quite High
opioid receptor 2 81.52 Quite High
Pain 5 78.12 Quite High
Kinase C 18 70.44 Quite High
qutenza 29 58.84 Quite High
Spinal cord 15 50.00 Quite Low
intrathecal 6 43.92 Quite Low
Disease Link Frequency Relevance Heat
Nociception 17 86.40 High High
Nervous System Injury 1 17.20 Low Low
INFLAMMATION 1 13.12 Low Low
Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.
Phosphorylation (phosphorylated) of CREB Spec (may) Regulation (participate) of c-Jun
1) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.43 Pain Relevance 0.72

General Comments

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