INT186441

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 12 100.00 Very High Very High Very High
antagonist 3 95.72 Very High Very High Very High
Kappa opioid receptor 8 93.52 High High
Dorsal horn neuron 2 92.92 High High
Glutamate receptor 3 91.04 High High
Neuropathic pain 1 90.12 High High
Pain 28 88.64 High High
qutenza 29 84.88 Quite High
Lasting pain 13 77.96 Quite High
Spinal cord 19 77.52 Quite High
Disease Link Frequency Relevance Heat
Nociception 20 96.56 Very High Very High Very High
Neuropathic Pain 1 90.12 High High
Pain 40 88.64 High High
Disease 1 79.96 Quite High
Arthritis 5 79.60 Quite High
INFLAMMATION 2 77.44 Quite High
Nervous System Injury 1 75.48 Quite High
Repression 5 71.92 Quite High
Frailty 29 46.36 Quite Low
Hypersensitivity 1 11.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of MAP kinase signaling was also reported to be involved in the transcriptional regulation of prodynorphin and neurokinin-1 (NK-1) gene products [5,14,16,35].
Regulation (involved) of Regulation (regulation) of dynorphin
1) Confidence 0.26 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.39 Pain Relevance 0.58
Carrion and colleagues [8,9] showed the binding of DREAM to DNA, which implied a role in the hierarchical machinery regulating the rat dynorphin-encoding prodynorphin (pdyn) gene in a Ca2+-dependent manner.
Regulation (role) of Regulation (regulating) of dynorphin-encoding prodynorphin associated with dynorphin
2) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.42 Pain Relevance 1.34

General Comments

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