INT186443

Context Info Confidence 0.49 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0.73

nucleoplasm (Creb1, FOS) nucleolus (Creb1, FOS) nucleus (Creb1, FOS) mitochondrion (Creb1) aging (FOS) DNA binding (Creb1)

Creb1 (Rattus norvegicus) FOS (Homo sapiens)

Pain Link Frequency Relevance Heat central sensitization 13 86.84 Glutamate receptor 3 84.48 Dynorphin 2 83.60 Enkephalin 2 82.72 opioid receptor 2 81.52 Pain 5 80.40 Kinase C 18 72.72 qutenza 29 61.12 Spinal cord 15 50.00 intrathecal 6 46.20

Disease Link Frequency Relevance Heat Nociception 17 86.40 Nervous System Injury 1 17.20 INFLAMMATION 1 13.12 Pain 2 5.00 Hypersensitivity 1 5.00 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Like other transcription factors, such as AP-1 proteins, c-fos, and c-Jun, phosphorylated CREB may participate in the downstream signal transduction cascade in the longer lasting changes in synaptic plasticity.

Phosphorylation (phosphorylated) of CREB Spec (may) Regulation (participate) of Transcription (transcription) of c-fos

1) Confidence 0.49 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.44 Pain Relevance 0.73

General Comments

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