INT186450

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.94
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPB) extracellular region (SFTPB) lipid metabolic process (SFTPB)
lysosome (SFTPB) cytoplasm (SFTPB)
Anatomy Link Frequency
respiratory 4
tube 1
lung 1
SFTPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 158 97.64 Very High Very High Very High
imagery 23 72.92 Quite High
fibrosis 122 58.40 Quite High
anesthesia 11 43.92 Quite Low
cva 26 5.00 Very Low Very Low Very Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
corticosteroid 15 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 236 99.84 Very High Very High Very High
Respiratory Distress 144 99.84 Very High Very High Very High
Apnoea 6 99.52 Very High Very High Very High
Adult Respiratory Distress Syndrome 280 99.44 Very High Very High Very High
Infection 50 98.20 Very High Very High Very High
INFLAMMATION 154 97.64 Very High Very High Very High
Pulmonary Disease 203 96.08 Very High Very High Very High
Interstitial Lung Diseases 288 94.56 High High
Pneumonia 77 89.44 High High
Congenital Anomalies 70 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g total protein each were prepared to detect (Pro-)SP-B and (Pro-)SP-C under reducing and SP-B and SP-C under non reducing conditions.
Negative_regulation (reducing) of SP-B
1) Confidence 0.58 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.07 Pain Relevance 0
Based on our results, the biochemical analysis of BAL fluid for mature SP-B, previously thought to be diagnostic for SP-B deficiency, is not 100% specific, as there are additional cause(s) leading to a lack of SP-B.
Negative_regulation (lack) of SP-B
2) Confidence 0.55 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.52 Pain Relevance 0
In conclusion our data do not support, if not contradict, the notion of down-regulation of SP-B and SP-C during acute and chronic bronchial infection and inflammation in the investigated human lung diseases.


Negative_regulation (regulation) of SP-B in lung associated with pulmonary disease, inflammation and infection
3) Confidence 0.43 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.63 Pain Relevance 0.19
Based on our results, the biochemical analysis of BAL fluid for mature SP-B, previously thought to be diagnostic for SP-B deficiency, is not 100% specific, as there are additional cause(s) leading to a lack of SP-B.
Negative_regulation (deficiency) of SP-B
4) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.58 Pain Relevance 0
In addition, 7 subjects with chronic respiratory distress of unknown cause, in the absence of SP-B deficiency or alveolar proteinosis were investigated.
Negative_regulation (deficiency) of SP-B in respiratory associated with pulmonary alveolar proteinosis and respiratory distress
5) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 1.74 Pain Relevance 0
However, we found pro-SP-C forms that were clearly, but not exclusively, associated with SP-B deficiency or SFTPC mutation.
Negative_regulation (deficiency) of SP-B
6) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.20 Pain Relevance 0
Consistent with our data, this group also found that, in contrast to patients with congenital respiratory distress due to SP-B deficiency, the appearance of pro-SP-C forms in these PAP patients was a rare occurrence.
Negative_regulation (deficiency) of SP-B in respiratory associated with pulmonary alveolar proteinosis and respiratory distress
7) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.55 Pain Relevance 0
Overall pro-SP-C forms were rarely detected, and their presence was specific, but not pathognomonic for a SP-B deficiency due to SFTPB mutations.
Negative_regulation (deficiency) of SP-B
8) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.63 Pain Relevance 0
At T0, a severe and highly significant reduction in SP-A, SP-B and SP-C, the LA fraction, PC and phosphatidylglycerol (PG) percentages, and dipalmitoylation of PC (DPPC) was encountered.
Negative_regulation (reduction) of SP-B
9) Confidence 0.33 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1950506 Disease Relevance 0.49 Pain Relevance 0
In line with our data, they found decreased SP-A and SP-B levels compared to controls, but SP-A remained consistently low during the observation period (14 days).
Negative_regulation (decreased) of SP-B
10) Confidence 0.33 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0.95 Pain Relevance 0
SP-A [5,6], SP-B [5,6] and SP-C levels [7] were decreased, the relative phosphatidylcholine palmitic acid content was reduced [3,8], and a marked reduction in phosphatidylglycerol (PG) has been observed throughout.
Negative_regulation (reduced) of SP-B
11) Confidence 0.29 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0.82 Pain Relevance 0.04
SP-A [5,6], SP-B [5,6] and SP-C levels [7] were decreased, the relative phosphatidylcholine palmitic acid content was reduced [3,8], and a marked reduction in phosphatidylglycerol (PG) has been observed throughout.
Negative_regulation (decreased) of SP-B
12) Confidence 0.29 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0.82 Pain Relevance 0.04
BAL was available from 6 (URD 31-II.3, 40-II.1, 36-II.2, 30-II.1, 39-II.1, 37-II.2) of the initial 15 patients and from another infant born at 36 wks of gestation, with acute respiratory distress and development of chronic respiratory distress of unknown cause, after exclusion of SP-B, SP-C deficiency, and pulmonary alveolar proteinosis.
Negative_regulation (deficiency) of SP-B in respiratory associated with pulmonary alveolar proteinosis and respiratory distress
13) Confidence 0.18 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 1.37 Pain Relevance 0
The hydrophobic surfactant proteins SP-B and SP-C as well as SP-A, but not SP-D, were found to be significantly reduced (Table 2).
Negative_regulation (reduced) of SP-B
14) Confidence 0.14 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0
More than 30 SFTPB (located on chromosome 2) mutations have been identified among patients with a congenital deficiency in SP-B.
Negative_regulation (deficiency) of SP-B
15) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.50 Pain Relevance 0
The deficiency in SP-B is a rare autosomal recessive condition known to be responsible for lethal neonatal respiratory distress.
Negative_regulation (deficiency) of SP-B in respiratory associated with respiratory distress
16) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.88 Pain Relevance 0.04
Although PSRs were exposed to higher transpulmonary pressures during PAV than during CPAP both after surfactant-depletion and instillation of surfactant (Table 1), apnea was not elicited in any of the cats studied.
Negative_regulation (depletion) of surfactant associated with apnoea
17) Confidence 0.00 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0.10 Pain Relevance 0
To achieve surfactant depletion similar to that in RDS, lung lavage was performed 7–8 times through the endotracheal tube with saline (30 mL/kg) heated to +37.5°C [24].
Negative_regulation (depletion) of surfactant in tube associated with respiratory distress
18) Confidence 0.00 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0.10 Pain Relevance 0

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