INT186452

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2006
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.43
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPB) extracellular region (SFTPB) lipid metabolic process (SFTPB)
lysosome (SFTPB) cytoplasm (SFTPB)
Anatomy Link Frequency
lung 2
respiratory 2
SFTPB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6 63.48 Quite High
anesthesia 7 47.36 Quite Low
Inflammation 6 42.20 Quite Low
corticosteroid 6 36.16 Quite Low
Disease Link Frequency Relevance Heat
Respiratory Distress 109 99.50 Very High Very High Very High
Lung Injury 7 99.08 Very High Very High Very High
Pulmonary Alveolar Proteinosis 180 98.88 Very High Very High Very High
Pulmonary Disease 90 95.96 Very High Very High Very High
Weight Loss 6 95.16 Very High Very High Very High
Chlamydia Infection 6 94.68 High High
Asthenia 6 94.56 High High
Bacterial Respiratory Disease 6 94.24 High High
Failure To Thrive 6 93.20 High High
Coronary Heart Disease 6 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All but 2 subjects had mutations of SP-B as the cause for the SP-B deficiency.
Positive_regulation (cause) of SP-B
1) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 1.50 Pain Relevance 0.03
In all these patients mutations of SP-B were excluded, 3 patients (PAP 04, PAP 10 and PAP 12) had heterozygous mutations in SFTPC.
Positive_regulation (mutations) of SP-B associated with pulmonary alveolar proteinosis
2) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 1.75 Pain Relevance 0
The presence of these relatively rarely observed bands at 11 to 15 kDa was not related to specific clinical features of the subjects, i.e. more pronounced lung injury, high protein to phospholipids ratio or high abundance of SP-B.
Positive_regulation (abundance) of SP-B in lung associated with lung injury
3) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.52 Pain Relevance 0
The infants with chronic respiratory distress of unknown cause had no mutations of SFTPB or SFTPC, and normal SP-B and SP-C in their lavages (Tab. 1).
Neg (no) Positive_regulation (mutations) of SP-B in respiratory associated with respiratory distress
4) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.85 Pain Relevance 0
Of the 6 patients with SP-B deficiency defined as a lack of mature SP-B on Western blotting, 4 had mutations in SFTPB (Tab. 3).
Positive_regulation (mutations) of SFTPB
5) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.61 Pain Relevance 0
The infants with chronic respiratory distress of unknown cause had no mutations of SFTPB or SFTPC, and normal SP-B and SP-C in their lavages (Tab. 1).
Neg (no) Positive_regulation (mutations) of SFTPB in respiratory associated with respiratory distress
6) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.85 Pain Relevance 0
In the present study, lung compliance was low after lung lavage, but increased after instillation of surfactant.
Positive_regulation (increased) of surfactant in lung
7) Confidence 0.00 Published 2006 Journal Respir Res Section Body Doc Link PMC1420291 Disease Relevance 0.35 Pain Relevance 0

General Comments

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