INT186455

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.24
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPB) extracellular region (SFTPB) lipid metabolic process (SFTPB)
lysosome (SFTPB) cytoplasm (SFTPB)
Anatomy Link Frequency
Clara cells 1
SFTPB (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 133 83.20 Quite High
Inflammation 129 81.20 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 42 99.36 Very High Very High Very High
Bacterial Pneumonia 4 95.04 Very High Very High Very High
Bacterial Respiratory Disease 5 86.52 High High
Bronchopulmonary Dysplasia 1 84.96 Quite High
Lung Injury 17 83.88 Quite High
Cystic Fibrosis 129 83.76 Quite High
INFLAMMATION 121 81.20 Quite High
Infection 32 71.20 Quite High
Pulmonary Disease 27 66.32 Quite High
Pneumocystis Carinii Infection 8 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are some data available on the levels of SP-B in the alveolar space, but almost no data on the molecular organization of SP-B and of pro-SP-B during various disease states [10].
Localization (organization) of SP-B associated with disease
1) Confidence 0.74 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.11 Pain Relevance 0.19
SP-B is synthesized by alveolar type II cells to the mature 8 kDa protein and secreted into the alveolar space, where it is mainly found as a dimer [5].
Localization (secreted) of SP-B
2) Confidence 0.70 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.38 Pain Relevance 0.07
Instead, a 24 kDa proSP-B form is secreted into the alveolar space.
Localization (secreted) of SP-B
3) Confidence 0.68 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.40 Pain Relevance 0.07
Thus, this intermediate represents a normal pro-SP-B processing intermediate of SP-B biosynthesis and could result from either constitutive secretion of this form by type II cells or from the physiologic release of 25 kD pro-SP-B into the airways by Clara cells.
Localization (release) of SP-B in Clara cells
4) Confidence 0.66 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.21 Pain Relevance 0
There are some data available on the levels of SP-B in the alveolar space, but almost no data on the molecular organization of SP-B and of pro-SP-B during various disease states [10].
Localization (organization) of SP-B associated with disease
5) Confidence 0.65 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.13 Pain Relevance 0.20

General Comments

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