INT186456

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 11.46
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPC) extracellular region (SFTPC) cytoplasm (SFTPC)
Anatomy Link Frequency
lung 3
granulocytes 2
pneumocytes 1
band 1
neutrophil 1
SFTPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 257 99.96 Very High Very High Very High
fibrosis 265 98.08 Very High Very High Very High
corticosteroid 1 47.48 Quite Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 241 99.96 Very High Very High Very High
Pulmonary Alveolar Proteinosis 30 99.68 Very High Very High Very High
Infection 64 99.62 Very High Very High Very High
Lung Injury 33 99.62 Very High Very High Very High
Pneumonia 112 99.42 Very High Very High Very High
Asthma 17 99.36 Very High Very High Very High
Pneumocystis Carinii Infection 16 98.52 Very High Very High Very High
Aspergillus Infection 16 98.18 Very High Very High Very High
Cystic Fibrosis 257 98.08 Very High Very High Very High
Hyperoxia 8 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subject PAP 08, a patient with a heterozygous SFTPC mutation and previously described in detail, had 3 bands, and subject PAP 04, in whom no SP-C mutation was detected, had one band at 6 kD [17].
Neg (no) Gene_expression (detected) of SP-C in band associated with pulmonary alveolar proteinosis
1) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.90 Pain Relevance 0
This result is surprising, especially for SP-C, as recently in various animal models of lung injury the regulation of SP-C expression by inflammation has been highlighted [1].
Gene_expression (expression) of SP-C in lung associated with lung injury and inflammation
2) Confidence 0.75 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.04 Pain Relevance 0.28
Although we found no evidence for down-regulation of SP-C expression by pulmonary infection and inflammation, SP-C was not detected in the samples of three patients with very high percentages of neutrophile granulocytes in their lavages.
Neg (not) Gene_expression (detected) of SP-C in granulocytes associated with inflammation and infection
3) Confidence 0.75 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.99 Pain Relevance 0.31
Although we found no evidence for down-regulation of SP-C expression by pulmonary infection and inflammation, SP-C was not detected in the samples of three patients with very high percentages of neutrophile granulocytes in their lavages.
Gene_expression (expression) of SP-C in granulocytes associated with inflammation and infection
4) Confidence 0.75 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.94 Pain Relevance 0.29
In contrast, in the BALF-samples CF 20-2 and CF 21-2, which were taken from the patients CF 20 and CF 21 at a time were they had a lower level of pulmonary inflammation (57% and 43% neutrophiles), SP-C was regularly detected (Fig. 1B).
Gene_expression (detected) of SP-C associated with fibrosis, inflammation and pneumonia
5) Confidence 0.65 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.79 Pain Relevance 0.80
Recently in various animal models of lung injury the regulation of SP-C expression by inflammation has been highlighted.
Gene_expression (expression) of SP-C in lung associated with lung injury and inflammation
6) Confidence 0.58 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.81 Pain Relevance 0.16
SP-C concentrations were reduced in bleomycin induced lung fibrosis, hyperoxia, Aspergillus fumigatus and Pneumocystis jiroveci infections and a model of asthma, suggesting down-regulation of SP-C expression by pulmonary infection and inflammation.
Gene_expression (expression) of SP-C in lung associated with pneumocystis carinii infection, pulmonary fibrosis, infection, fibrosis, asthma, inflammation, hyperoxia and aspergillus infection
7) Confidence 0.58 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.67 Pain Relevance 0.18
SP-B was detected in BAL of all 64 patients, whereas SP-C was found in BAL of all but 3 children; those three BAL fluids had more than 80% neutrophils, and in two patients, who were re-lavaged later, SP-C was then present and the neutrophil count was lower.
Gene_expression (found) of SP-C in neutrophil
8) Confidence 0.58 Published 2008 Journal BMC Pulm Med Section Abstract Doc Link PMC2364613 Disease Relevance 0.83 Pain Relevance 0.20
SP-C is exclusively synthesized by alveolar type II pneumocytes and secreted into the alveolar space [19].
Gene_expression (synthesized) of SP-C in pneumocytes
9) Confidence 0.58 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.49 Pain Relevance 0.16

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