INT186458

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.60
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPC) extracellular region (SFTPC) cytoplasm (SFTPC)
Anatomy Link Frequency
granulocytes 1
lung 1
respiratory 1
SFTPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 189 98.88 Very High Very High Very High
fibrosis 170 90.08 High High
anesthesia 7 43.92 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 30 99.76 Very High Very High Very High
Infection 40 99.28 Very High Very High Very High
Respiratory Distress 16 99.12 Very High Very High Very High
INFLAMMATION 178 98.88 Very High Very High Very High
Adult Respiratory Distress Syndrome 254 98.84 Very High Very High Very High
Pulmonary Disease 54 96.44 Very High Very High Very High
Fever 19 94.12 High High
Cystic Fibrosis 161 90.08 High High
Pneumonia 107 88.84 High High
Pneumocystis Pneumonia 10 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g total protein each were prepared to detect (Pro-)SP-B and (Pro-)SP-C under reducing and SP-B and SP-C under non reducing conditions.
Negative_regulation (reducing) of SP-C
1) Confidence 0.57 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.07 Pain Relevance 0
These data suggest loss of SP-C by proteolysis with severe inflammation, but not down-regulation from inflammation.
Negative_regulation (loss) of SP-C associated with inflammation
2) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.39 Pain Relevance 0.41
Apart from the loss of SP-C in the samples of three patients with very high amounts of neutrophile granulocytes in their lavages, which was probably due to proteolysis, no significant correlation could be observed between the level of neutrophilic inflammation and the amounts of SP-B and SP-C in the lavage samples.
Negative_regulation (loss) of SP-C in granulocytes associated with inflammation
3) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.68 Pain Relevance 0.24
In conclusion our data do not support, if not contradict, the notion of down-regulation of SP-B and SP-C during acute and chronic bronchial infection and inflammation in the investigated human lung diseases.


Negative_regulation (regulation) of SP-C in lung associated with pulmonary disease, inflammation and infection
4) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.63 Pain Relevance 0.19
The available data contradict or only in part support the notion of a down-regulation of SP-C during pulmonary infection and inflammation.
Negative_regulation (regulation) of SP-C associated with inflammation and infection
5) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 2.01 Pain Relevance 0.37
BAL was available from 6 (URD 31-II.3, 40-II.1, 36-II.2, 30-II.1, 39-II.1, 37-II.2) of the initial 15 patients and from another infant born at 36 wks of gestation, with acute respiratory distress and development of chronic respiratory distress of unknown cause, after exclusion of SP-B, SP-C deficiency, and pulmonary alveolar proteinosis.
Negative_regulation (deficiency) of SP-C in respiratory associated with pulmonary alveolar proteinosis and respiratory distress
6) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 1.37 Pain Relevance 0
SP-A [5,6], SP-B [5,6] and SP-C levels [7] were decreased, the relative phosphatidylcholine palmitic acid content was reduced [3,8], and a marked reduction in phosphatidylglycerol (PG) has been observed throughout.
Negative_regulation (decreased) of SP-C
7) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0.81 Pain Relevance 0.04
The hydrophobic surfactant proteins SP-B and SP-C as well as SP-A, but not SP-D, were found to be significantly reduced (Table 2).
Negative_regulation (reduced) of SP-C
8) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0 Pain Relevance 0
At T0, a severe and highly significant reduction in SP-A, SP-B and SP-C, the LA fraction, PC and phosphatidylglycerol (PG) percentages, and dipalmitoylation of PC (DPPC) was encountered.
Negative_regulation (reduction) of SP-C
9) Confidence 0.42 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1950506 Disease Relevance 0.49 Pain Relevance 0
SP-A [5,6], SP-B [5,6] and SP-C levels [7] were decreased, the relative phosphatidylcholine palmitic acid content was reduced [3,8], and a marked reduction in phosphatidylglycerol (PG) has been observed throughout.
Negative_regulation (reduced) of SP-C
10) Confidence 0.42 Published 2007 Journal Respir Res Section Body Doc Link PMC1950506 Disease Relevance 0.82 Pain Relevance 0.04
In the case of SP-C, this may suggest a stabilization of type-II cell integrity and surfactant homeostasis under the indicated treatment regimes as previous studies showed significantly reduced SP-C levels in BAL specimen from conventionally ventilated ARDS patients [25].
Negative_regulation (reduced) of SP-C associated with adult respiratory distress syndrome
11) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2483254 Disease Relevance 0.33 Pain Relevance 0

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