INT186463

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.52
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPC) extracellular region (SFTPC) cytoplasm (SFTPC)
Anatomy Link Frequency
granulocytes 4
band 2
lung 2
SFTPC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 97 98.88 Very High Very High Very High
fibrosis 100 97.88 Very High Very High Very High
corticosteroid 1 47.48 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 7 99.74 Very High Very High Very High
Pulmonary Alveolar Proteinosis 30 99.68 Very High Very High Very High
Infection 24 99.44 Very High Very High Very High
Pneumocystis Carinii Infection 6 98.90 Very High Very High Very High
INFLAMMATION 91 98.88 Very High Very High Very High
Aspergillus Infection 6 98.56 Very High Very High Very High
Hyperoxia 3 98.10 Very High Very High Very High
Pulmonary Fibrosis 3 97.88 Very High Very High Very High
Lung Injury 13 95.56 Very High Very High Very High
Respiratory Distress 16 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP-C concentrations were reduced in bleomycin induced lung fibrosis, hyperoxia, Aspergillus fumigatus and Pneumocystis jiroveci infections and a model of asthma, suggesting down-regulation of SP-C expression by pulmonary infection and inflammation.
Negative_regulation (down-regulation) of Gene_expression (expression) of SP-C in lung associated with pneumocystis carinii infection, pulmonary fibrosis, infection, fibrosis, asthma, inflammation, hyperoxia and aspergillus infection
1) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 1.73 Pain Relevance 0.18
Although we found no evidence for down-regulation of SP-C expression by pulmonary infection and inflammation, SP-C was not detected in the samples of three patients with very high percentages of neutrophile granulocytes in their lavages.
Negative_regulation (down) of Gene_expression (expression) of SP-C in granulocytes associated with inflammation and infection
2) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.94 Pain Relevance 0.29
Although we found no evidence for down-regulation of SP-C expression by pulmonary infection and inflammation, SP-C was not detected in the samples of three patients with very high percentages of neutrophile granulocytes in their lavages.
Negative_regulation (regulation) of Gene_expression (expression) of SP-C in granulocytes associated with inflammation and infection
3) Confidence 0.42 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2364613 Disease Relevance 0.94 Pain Relevance 0.29
Subject PAP 08, a patient with a heterozygous SFTPC mutation and previously described in detail, had 3 bands, and subject PAP 04, in whom no SP-C mutation was detected, had one band at 6 kD [17].
Negative_regulation (detected) of Neg (no) Gene_expression (detected) of SP-C in band associated with pulmonary alveolar proteinosis
4) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1224872 Disease Relevance 0.90 Pain Relevance 0

General Comments

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