INT186468

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 5.05
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
cleavage 4
EL4 4
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 43 99.98 Very High Very High Very High
imagery 52 77.20 Quite High
withdrawal 9 23.60 Low Low
cytokine 2 12.00 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
Restless leg syndrome 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 485 99.84 Very High Very High Very High
Lymphatic System Cancer 21 99.28 Very High Very High Very High
Apoptosis 284 95.64 Very High Very High Very High
Death 72 92.96 High High
Osteoporosis 27 88.80 High High
Necrosis 10 64.16 Quite High
Breast Cancer 4 62.48 Quite High
Lymphoid Leukemia 3 50.00 Quite Low
Malignant Neoplastic Disease 57 25.12 Quite Low
Prostate Cancer 3 16.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the time-dependent cleavage of PARP-1 followed the rapid and transient activation of caspase-3 after cytotoxic drug treatment or ionizing radiation in vitro (data not shown).
Positive_regulation (dependent) of Protein_catabolism (cleavage) of PARP-1 in cleavage
1) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.95 Pain Relevance 0.03
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Positive_regulation (induced) of Protein_catabolism (cleavage) of PARP-1 in EL4 associated with lymphatic system cancer and cancer
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.52 Pain Relevance 0.04
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Positive_regulation (dependent) of Protein_catabolism (cleavage) of PARP-1 in EL4 associated with lymphatic system cancer and cancer
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.51 Pain Relevance 0.04
We raised the question whether treatment of CEM cells with PADMA 28 causes a caspase 3- or 7-mediated proteolytic cleavage of PARP.
Spec (whether) Positive_regulation (causes) of Protein_catabolism (cleavage) of PARP in cleavage
4) Confidence 0.26 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.27 Pain Relevance 0
Dex induces cleavage of PARP in osteoblasts
Positive_regulation (induces) of Protein_catabolism (cleavage) of PARP associated with dexamethasone
5) Confidence 0.10 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.81 Pain Relevance 0.23

General Comments

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