INT18647

Context Info Confidence 0.78 First Reported 1988 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 16 Total Number 17 Disease Relevance 4.04 Pain Relevance 9.77

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1) plasma membrane (YY1) nucleus (YY1) intracellular (YY1)

Anatomy Link Frequency plasma 1 nerve 1 neurons 1 brain 1 cornea 1 YY1 (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 29 100.00 agonist 19 100.00 Delta opioid receptors 7 100.00 opiate 5 100.00 Kinase C 2 99.98 Opioid 20 99.96 Enkephalin 38 99.66 Kappa opioid receptor 6 99.32 MU agonist 19 98.68 tolerance 5 98.18

Disease Link Frequency Relevance Heat Cancer 4 97.68 Pain 2 94.48 Syndrome 20 92.64 INFLAMMATION 7 90.08 Attention Deficit Hyperactivity Disorder 4 89.88 Drug Dependence 1 87.20 Aggression 6 87.08 Personality Disorder 1 79.00 Disease 17 78.80 Pheochromocytoma 5 75.00

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Autoradiographic localization of delta opioid receptors within the mesocorticolimbic dopamine system using radioiodinated [2-D-penicillamine, 5-D-penicillamine]enkephalin (125I-DPDPE).

Localization (localization) of delta associated with dopamine, enkephalin and delta opioid receptors

1) Confidence 0.78 Published 1990 Journal Synapse Section Title Doc Link 1978419 Disease Relevance 0 Pain Relevance 0.82

Autoradiographic localization of delta opiate receptors in rat and human brain.

Localization (localization) of delta in brain associated with enkephalin and opiate

2) Confidence 0.78 Published 1988 Journal Neuroscience Section Title Doc Link 2851117 Disease Relevance 0.06 Pain Relevance 0.87

Co-localization of mu- and delta-opioid receptors on SK-N-SH cells has been studied by double labeling fluorescence experiments.

Localization (Co-localization) of delta in SK-N-SH associated with delta opioid receptors

3) Confidence 0.78 Published 1993 Journal Life Sci. Section Abstract Doc Link 8387131 Disease Relevance 0 Pain Relevance 0.23

K(+)-evoked acetylcholine release in the presence of TTX was inhibited by U50488, but not by DPDPE, suggesting the presence of kappa-opioid receptors on cholinergic terminals and the localization of delta-receptors on cortical interneurons.

Localization (localization) of delta in interneurons associated with kappa opioid receptor

4) Confidence 0.78 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8938656 Disease Relevance 0 Pain Relevance 1.02

According to a cDNA microarray analysis, mRNA of protein kinase C-delta (PKC-delta), prostaglandin D synthase, and arachidonate release-relating enzymes were significantly overexpressed in the tumor tissue in comparison to the adjacent nontumor tissue.

Localization (release) of delta associated with kinase c and cancer

5) Confidence 0.73 Published 2009 Journal Horm. Metab. Res. Section Abstract Doc Link 19048456 Disease Relevance 1.40 Pain Relevance 0.42

DISCUSSION: Both mu and delta-receptors are localized on nerve fibers within the cornea, which are accessible for topical opioid treatment.

Localization (localized) of delta in cornea

6) Confidence 0.73 Published 2008 Journal Clin J Pain Section Body Doc Link 18806534 Disease Relevance 0 Pain Relevance 0

Thus, we conclude that pharmacological chaperones facilitate plasma membrane targeting of delta-opioid receptors by binding and stabilizing receptor precursors, thereby promoting their release from the stringent ER quality control.

Localization (release) of delta in plasma associated with delta opioid receptors

7) Confidence 0.73 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17550902 Disease Relevance 0 Pain Relevance 0.48

Phe27Cys polymorphism alters the maturation and subcellular localization of the human delta opioid receptor.

Localization (localization) of delta associated with opioid receptor

8) Confidence 0.68 Published 2009 Journal Traffic Section Title Doc Link 19000170 Disease Relevance 0.18 Pain Relevance 0.24

The effects of mu, delta and kappa receptor agonists on both basal and LH-induced progesterone (P4) secretion were negligible.

Localization (secretion) of delta associated with agonist

9) Confidence 0.68 Published 2004 Journal Reprod. Domest. Anim. Section Abstract Doc Link 15129917 Disease Relevance 0 Pain Relevance 0.72

Cellular tolerance to delta-opioid agonists involves feedback-regulation of the function, concentration, and localization of the delta-opioid receptors (receptor desensitization) as well as of intracellular effectors (functional desensitization).

Localization (localization) of delta associated with mu agonist, tolerance and delta opioid receptors

10) Confidence 0.68 Published 2003 Journal Acta. Biol. Hung. Section Abstract Doc Link 14535626 Disease Relevance 0 Pain Relevance 0.65

However, it is not known whether the release of kappa- and delta-opioids is also concomitantly regulated.

Spec (whether) Localization (release) of delta associated with opioid

11) Confidence 0.68 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538829 Disease Relevance 0 Pain Relevance 0.84

Using primary antisera directed toward cloned opioid receptors, delta-opioid receptor immunoreactivity was immunohistochemically localized in submucosal neurons and nerve fibers, but immunoreactivities to kappa- or mu-opioid receptors were not detected in the mucosa-submucosa.

Localization (localized) of delta in nerve associated with mu opioid receptor and opioid receptor

12) Confidence 0.68 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303057 Disease Relevance 0 Pain Relevance 1.49

In situ hybridization histochemistry and immunocytochemistry were used to study localization and activity-dependent regulation of alpha, beta, gamma, and delta isoforms of type II calcium/calmodulin-dependent protein kinase (CaMKII) and their mRNAs in areas 17 and 18 of normal and monocularly deprived adult macaques.

Localization (localization) of delta

13) Confidence 0.68 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.07

The actions of trimebutine [3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutylester] on the gastrointestinal tract are mediated via (i) an agonist effect on peripheral mu, kappa and delta opiate receptors and (ii) release of gastrointestinal peptides such as motilin and modulation of the release of other peptides, including vasoactive intestinal peptide, gastrin and glucagon.

Localization (release) of delta associated with agonist and opiate

14) Confidence 0.68 Published 1997 Journal J. Int. Med. Res. Section Abstract Doc Link 9364286 Disease Relevance 0.05 Pain Relevance 0.20

No significant correlations were found between the Log of Peak DeltaGH[CLON] response and any measure used in this study.

Localization (response) of DeltaGH

15) Confidence 0.50 Published 2010 Journal Psychiatry Res Section Abstract Doc Link 20483477 Disease Relevance 0.79 Pain Relevance 0.18

Treatment in CM is a process of regulating and re-establishing the balance of Yin and Yang through reducing the redundancy of Yin or Yang () and reinforcing the deficiency of Yin or Yang () [3].

Localization (redundancy) of Yin

16) Confidence 0.34 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1090607 Disease Relevance 1.50 Pain Relevance 0.05

Using primary antisera directed toward cloned opioid receptors, delta-opioid receptor immunoreactivity was immunohistochemically localized in submucosal neurons and nerve fibers, but immunoreactivities to kappa- or mu-opioid receptors were not detected in the mucosa-submucosa.

Localization (localized) of delta in neurons associated with mu opioid receptor and opioid receptor

17) Confidence 0.23 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303057 Disease Relevance 0 Pain Relevance 1.49

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